ArticleClinical anatomy (New York, N.Y.)2021
Splenic artery loops: Potential splenic plexus stimulation sites for neuroimmunomodulatory-based anti-inflammatory therapy?
Article in Clinical anatomy (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Multi-Organ Denervation: The Past, Present and Future.Journal of clinical medicine · 2025Review
- Exploring the topography of the splenic artery: a comprehensive analysis.Surgical and radiologic anatomy : SRA · 2025Article
- Morphological Evaluation of the Splenic Artery, Its Anatomical Variations and Irrigation Territory.Life (Basel, Switzerland) · 2023Article
- Electrical stimulation of the splenic nerve bundle ameliorates dextran sulfate sodium-induced colitis in mice.Journal of neuroinflammation · 2022Article
- Human-relevant near-organ neuromodulation of the immune system via the splenic nerve.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Splenic artery loops: Potential splenic plexus stimulation sites for neuroimmunomodulatory-based anti-inflammatory therapy?Clinical anatomy (New York, N.Y.) · 2021Article
- Morphometric analysis of the splenic artery using contrast-enhanced computed tomography (CT).Surgical and radiologic anatomy : SRA · 2021Article
- Age-Related Variation in Sympathetic Nerve Distribution in the Human Spleen.Frontiers in neuroscience · 2021Article
- Splenic Nerve Neuromodulation Reduces Inflammation and Promotes Resolution in Chronically Implanted Pigs.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionThe splenic plexus might represent a novel neuroimmunomodulatory therapeutic target as electrical stimulation of this tissue has been shown to have beneficial anti-inflammatory effects. Tortuous splenic artery segments (splenic artery loops), including their surrounding nerve plexus, have been evaluated as potential stimulation sites in humans. At present, however, our understanding of these loops and their surrounding nerve plexus is incomplete. This study aims to characterize the dimensions of these loops and their surrounding nerve tissue. MATERIALS AND
methodsSix formaldehyde fixed human cadavers were dissected and qualitative and quantitative macro- and microscopic data on splenic artery loops and their surrounding nerve plexus were collected.
resultsOne or multiple loops were observed in 83% of the studied specimens. These loops, including their surrounding nerve plexus could be easily dissected free circumferentially thereby providing sufficient space for further surgical intervention. The splenic plexus surrounding the loops contained a significant amount of nerves that contained predominantly sympathetic fibers.
conclusionThe results of this study support that splenic artery loops could represent suitable electrical splenic plexus stimulation sites in humans. Dimensions with respect to loop height and width, provide sufficient space for introduction of surgical instruments and electrode implantation, and, the dissected neurovascular bundles contain a substantial amount of sympathetic nerve tissue. This knowledge may contribute to further development of surgical techniques and neuroelectrode interface design.
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