Evidence map›Paper›PMID 32583799›Full record

ArticleeLife2020

The mitochondrial paradox.

Sophie L Penman, Rebecca L Jensen, Robyn T Kiy, Amy E Chadwick

Open access · goldAbstract readComment
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sophie L PenmanMRC Centre for Drug Safety Science, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0001-5326-1675
Rebecca L JensenMRC Centre for Drug Safety Science, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0003-1134-2869
Robyn T KiyMRC Centre for Drug Safety Science, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0001-7960-7283
Amy E ChadwickMRC Centre for Drug Safety Science, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0002-7399-8655
University of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A structural motif that is found in two cancer drugs may be responsible for their ability to tackle cancers and for the side-effects caused by the drugs.

Indexed as

Antineoplastic AgentsDrug-Related Side Effects and Adverse ReactionsNeoplasmsElectron Transport Complex IHumansMitochondriaAntineoplastic AgentsElectron Transport Complex Ianti-cancer drugsbiochemistrycancer biologycardiac liabilitychemical biologyhumanmitochondriatoxicophore

Identifiers

PMID32583799
PMCPMC7316502
OpenAlexW3038115073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.