Evidence map›Paper›PMID 32583738›Full record

ArticleMolecular biology of the cell2020

Rapidly dynamic host cell heterogeneity in bacterial adhesion governs susceptibility to infection by

Michelle Rengarajan, Julie A Theriot

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Bacterial aggregation facilitates internalin-mediated invasion ofFrontiers in cellular and infection microbiology · 2024
    Article
  4. Article
  5. Review
  6. The Interplay of Host Lysosomes and Intracellular Pathogens.Frontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Michelle RengarajanDepartment of Medicine, Massachusetts General Hospital, Boston, MA 02114.
Julie A TheriotDepartment of Biology, University of Washington, Seattle, WA 98185-1800.
Massachusetts General Hospital · USUniversity of Washington · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8M
TRAINING & OUTREACH COREP50GM107615 · NIGMS · STANFORD UNIVERSITY · PI COVERT, MARKUS W · 2013 to 2017
$10.9M
Actin-Based Motility of a Bacterial PathogenR37AI036929 · NIAID · UNIVERSITY OF WASHINGTON · PI THERIOT, JULIE A. · 2010 to 2019
$3.0M
ACTIN BASED MOTILITY OF A BACTERIAL PATHOGENR01AI036929 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI THERIOT, JULIE A. · 1995 to 2009
$2.2M
BD Canto II RUO CytometerS10RR027431 · NCRR · STANFORD UNIVERSITY · PI NOLAN, GARRY P · 2010 to 2010
$236k
Howard Hughes Medical InstituteNCRR NIH HHS S10 RR027431NIAID NIH HHS R01 AI036929NIAID NIH HHS R37 AI036929NIGMS NIH HHS P50 GM107615NIGMS NIH HHS T32 GM007365
6 · The paper itself

Abstract

Interactions between host cells and individual pathogenic bacteria determine the clinical severity of disease during systemic infection in humans. Vascular endothelial cells, which line the lumen of blood vessels, represent a critical barrier for a bacterium in the bloodstream. These cells adopt a myriad of phenotypes that may modulate their susceptibility to infection; however, the precise determinants of their heterogeneity in susceptibility are not known. Here, we show that heterogeneity in susceptibility to

Indexed as

Bacterial AdhesionHost-Pathogen InteractionsHumansHuman Umbilical Vein Endothelial CellsListeria monocytogenesListeriosis

Identifiers

PMID32583738
PMCPMC7530904
OpenAlexW3036589494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.