Evidence map›Paper›PMID 32583604›Full record

ReviewMolecular nutrition & food research2021

Microbial Products and Metabolites Contributing to Alcohol-Related Liver Disease.

Bei Gao, Atoosa Emami, Shilpa Nath, Bernd Schnabl

Open access · greenAbstract readReview
In one paragraph

Review in Molecular nutrition & food research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bei GaoDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Atoosa EmamiDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Shilpa NathDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Bernd SchnablDepartment of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
University of California, San Diego · US

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
The Role of the Intestinal Mycobiome in Alcoholic Liver DiseaseR01AA024726 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2018 to 2026
$3.9M
Microbiome and intestinal innate immune response in alcoholic liver diseaseR01AA020703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHNABL, BERND G. · 2011 to 2020
$3.6M
Microbiome and Intestinal Innate Immune Response in Alcoholic Liver DiseaseR37AA020703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2021 to 2026
$2.5M
Microbiome as therapeutic target in alcoholic hepatitisU01AA026939 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FOUTS, DERRICK E, SCHNABL, BERND G. · 2018 to 2022
$1.7M
The role of pathobionts in alcoholic liver diseaseI01BX004594 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI Bernd G. Schnabl · 2019 to 2026
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BLRD VA I01 BX004594NIAAA NIH HHS R01 AA020703NIAAA NIH HHS R01 AA024726NIAAA NIH HHS R37 AA020703NIAAA NIH HHS U01 AA026939NIDDK NIH HHS P30 DK120515
6 · The paper itself

Abstract

As a serious public health concern, alcohol-related liver disease is associated with dysregulations in the intestinal barrier function and the gut microbiota. The liver and gut communicate via the gut-liver axis, through which microbial products and metabolites translocate to the liver. Here, the current knowledge of various microbial products and metabolites which contribute to the alcohol-related liver diseases, including bile acids, indole-3-acetic acid, butyrate, long-chain fatty acids, endotoxin, cytolysin, β-glucan, and candidalysin is reviewed. Some of these might serve as therapeutic targets for alcohol-related liver disease.

Indexed as

Gastrointestinal MicrobiomeAlcohol DrinkingAnimalsbeta-GlucansBile Acids and SaltsButyratesEndotoxinsFatty Liver, AlcoholicFungal ProteinsHumansIndoleacetic Acidsbeta-GlucansBile Acids and SaltsButyratesECE1 protein, Candida albicansEndotoxinsFungal Proteinsindoleacetic acidIndoleacetic Acidsalcoholic liver diseasemicrobiomemycobiome

Identifiers

PMID32583604
PMCPMC7758187
OpenAlexW3037095985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.