ArticleInternational journal of clinical practice2021
Serum levels of inflammatory markers CRP, ESR and albumin in relation to survival for patients with hepatocellular carcinoma.
Article in International journal of clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Incremental prognostic value of the systemic immune‑inflammation index, pan‑immune‑inflammation value, and modified glasgow prognostic score for severity assessment and outcome prediction in community‑acquired pneumonia.BMC pulmonary medicine · 2026Article
- Relationship Between the Lactate-to-Albumin Ratio and Acute Kidney Injury in Patients with Pulmonary Embolism: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Early prognostic value of the lactate-to-albumin ratio in severe acute pancreatitis with acute respiratory distress syndrome.Frontiers in medicine · 2026Article
- Personalized Mortality Risk Stratification in ALD- and MASLD-Related Hepatocellular Carcinoma Using a Machine Learning Approach.Metabolites · 2025Article
- Prognostic value of immune-inflammation and nutritional indices in advanced hepatocellular carcinoma patients receiving immunotherapy with compound Kushen injection.World journal of gastrointestinal oncology · 2025Article
- Observational
- Association between red cell distribution width-to-albumin ratio and short-term mortality in patients with sepsis-associated delirium: a retrospective study from the MIMIC-IV database.BMC anesthesiology · 2025Article
- Hypoalbuminemia, but not derived neutrophil to lymphocyte ratio (dNLR), predicts overall survival in neuroendocrine tumours undergoing peptide receptor radionuclide therapy: A retrospective, cohort study of 557 patients.Journal of neuroendocrinology · 2025Article
- Systemic Immune-Inflammation Index: A Promising, Non-Invasive Biomarker for Crohn's Disease Activity and Severity Assessment.International journal of general medicine · 2025Article
- INTERLEUKIN-6 AND INTERLEUKIN-10 AS BIOMARKERS OF HEPATOCELLULAR CARCINOMA PROGRESSION: A CROSS-SECTIONAL ANALYSIS OF NUTRITIONAL, CYTOKINE AND SURVIVAL PARAMETERS.Arquivos de gastroenterologia · 2025Article
- Exploring Associations and Mediating Factors between Multiple Trace Metals with Anemia in US Adults: Insight from NHANES 2017-2020.Nutrients · 2024Article
- Effectiveness of Web Applications on Improving Nutritional Status of Patients with Colorectal Cancer.Nutrients · 2024Article
- Inversed albumin-to-globulin ratio and underlying liver disease severity as a prognostic factor for survival in hepatocellular carcinoma patients undergoing transarterial chemoembolization.Diagnostic and interventional radiology (Ankara, Turkey) · 2023Article
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- The combination of hand grip strength and modified Glasgow prognostic score predicts clinical outcomes in patients with liver cancer.Frontiers in nutrition · 2023Article
- Effect of storage temperature and time on erythrocyte sedimentation rate.European journal of medical research · 2022Article
- Identification of 2 large size HCC phenotypes, with and without associated inflammation.Clinical practice (London, England) · 2022Article
- Prognostic Impact of Serum CRP Level in Head and Neck Squamous Cell Carcinoma.Frontiers in oncology · 2022Article
- Tin derived antimony/nitrogen-doped porous carbon (Sb/NPC) composite for electrochemical sensing of albumin from hepatocellular carcinoma patients.Mikrochimica acta · 2021Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 1 country.
Funding
Abstract
introductionHepatocellular carcinoma is associated with several chronic inflammatory conditions. It is increasingly understood that the inflammation may be part of the carcinogenic process and prognostically important.
objectiveTo evaluate the serum levels of three inflammation markers in relation to survival in HCC patients.
methodsWe retrospectively examined the serum levels of CRP, albumin and ESR, both singly and in combination, in relation to patient survival.
resultsSurvival worsened with increase in CRP or ESR or decrease in albumin levels. Combinations of CRP plus albumin or CRP plus ESR were associated with an even greater range of survival (3-fold), together with significant differences in maximum tumor diameter (PVT) and percent of patients with portal vein thrombosis (PVT). The triplet of CRP plus albumin plus ESR was associated with a sevenfold difference in survival, comparing low vs high parameter levels. These significant differences were found in patients with small or large tumors.
conclusionsCombinations of CRP with albumin or ESR or all three parameters together significantly related to differences in survival and to differences in MTD and percent PVT, in patients with both small and large size HCCs.
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