Evidence map›Paper›PMID 32583363›Full record

Observational studyJournal of gastrointestinal cancer2021

Dysregulated Expression of Apoptosis-Associated Genes and MicroRNAs and Their Involvement in Gastric Carcinogenesis.

Mayara Luciana Sallas, Diana Zapparoli, Mônica Pezenatto Dos Santos, Jéssica Nunes Pereira, Wilson Aparecido Orcini, Rita Luiza Peruquetti, Elizabeth Suchi Chen, Marilia de Arruda Cardoso Smith, Spencer Luiz Marques Payão, Lucas Trevizani Rasmussen

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of gastrointestinal cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Gastric cancer burden and regional disparities among Helicobacter pylori-positive patients in the Americas: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Pooled it
  2. Pooled it
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mayara Luciana SallasUniversidade do Sagrado Coração (USC), Bauru, São Paulo, Brazil.
Diana ZapparoliUniversidade do Sagrado Coração (USC), Bauru, São Paulo, Brazil.
Mônica Pezenatto Dos SantosUniversidade do Sagrado Coração (USC), Bauru, São Paulo, Brazil.
Jéssica Nunes PereiraUniversidade do Sagrado Coração (USC), Bauru, São Paulo, Brazil.
Wilson Aparecido OrciniUniversidade do Sagrado Coração (USC), Bauru, São Paulo, Brazil.
Rita Luiza PeruquettiUniversidade do Sagrado Coração (USC), Bauru, São Paulo, Brazil.
Elizabeth Suchi ChenUniversidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Marilia de Arruda Cardoso SmithUniversidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Spencer Luiz Marques PayãoFaculdade de Medicina de Marília (FAMEMA), Marilia, São Paulo, Brazil.
Lucas Trevizani RasmussenUniversidade do Sagrado Coração (USC), Bauru, São Paulo, Brazil. lucas.rasmussen@usc.br.ORCID http://orcid.org/0000-0002-9033-2257
Universidade Sagrado Coração · BRUniversidade Federal de São Paulo · BRFaculdade de Medicina de Marília · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/11371-5 and 2018/08481-1
6 · The paper itself

Abstract

purposeAnalyze the expression of caspase-9, Smac/DIABLO, XIAP, let-7a, and let-7b in patients with normal gastric tissue, chronic gastritis, and gastric adenocarcinoma.

methodsThe expression of caspase-9, Smac/DIABLO, XIAP, let-7a, and let-7b by qRT-PCR was analyzed in 158 samples from 53 patients with normal gastric mucosa, 86 with chronic gastritis, and 19 with gastric cancer.

resultsThe comparison between the gastric cancer and the control group revealed a decreased expression of caspase-9 in gastric cancer tissues; considering the Helicobacter pylor presence, comparable results were revealed. Smac/DIABLO was increased in gastric cancer cells, while XIAP demonstrated no significant difference in the gene expression. The microRNA analysis revealed a decreased expression of let-7a and let-7b in samples positive to H. pylori infection and in gastric cancer group, regardless of the presence of the bacterium.

conclusionOur study provided some evidence of low activity of the intrinsic apoptosis pathway, as well as the influence of H. pylori on let-7a and let-7b expression.

Indexed as

AdenocarcinomaAdultAgedApoptosisApoptosis Regulatory ProteinsBiomarkers, TumorBiopsyCarcinogenesisCaspase 9FemaleGastric MucosaGastritisGene Expression ProfilingGene Expression Regulation, NeoplasticHelicobacter InfectionsHelicobacter pyloriApoptosis Regulatory ProteinsBiomarkers, TumorCASP9 protein, humanCaspase 9DIABLO protein, humanMicroRNAsmirnlet7 microRNA, humanMitochondrial ProteinsXIAP protein, humanX-Linked Inhibitor of Apoptosis ProteinCaspase-9Gastric cancermiR-let-7amiR-let-7bSmac/DIABLOXIAP

Identifiers

PMID32583363
OpenAlexW3037168716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.