Trial reportObesity surgery2020
The Role of Ursodeoxycholic Acid (UDCA) in Cholelithiasis Management After One Anastomosis Gastric Bypass (OAGB) for Morbid Obesity: Results of a Monocentric Randomized Controlled Trial.
Trial report in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Pooled it
- Primary and Revisional One Anastomosis Gastric Bypass: A Systematic Review and GRADE-Based IFSO Position Statement.Obesity surgery · 2026Pooled it
- Mapping the Landscape of Marginal Ulcers After One Anastomosis Gastric Bypass: Incidence, Regional Trends, and Treatment Insights from a Systematic Review and Meta-analysis.Obesity surgery · 2025Pooled it
- Role of Ursodeoxycholic Acid in the Prevention of Gallstones Formation in Bariatric Patients-a Systematic Review and Meta-Analysis of Randomised Trials.Obesity surgery · 2023Pooled it
- Marginal Ulcers Following One-Anastomosis Gastric Bypass: a Systematic Review and Meta-analysis.Obesity surgery · 2023Pooled it
- Risk Factors for Symptomatic Gallstone Disease and Gallstone Formation After Bariatric Surgery.Obesity surgery · 2022Trial
- Does antrum size matter in sleeve gastrectomy? A prospective randomized study.Surgical endoscopy · 2021Trial
- Polyphyllin II inhibits thyroid cancer progression by targeting HRH1 and suppressing Wnt/β‑catenin signaling.Oncology reports · 2026Article
- Obesity Hypoventilation Syndrome (OHS) as A Chronic Inflammatory Disease: A Clinical Case.Clinical case reports · 2026Article
- Bile acids and nanotechnology as emerging platforms for drug delivery.Therapeutic delivery · 2026Review
- Behavioral Therapy Ameliorates Severe Obesity With Low Levels of Plasma GH and IGF-1: A Case Report.Clinical case reports · 2026Article
- Hyperuricemia Remission After Sleeve Gastrectomy in Chinese Patients and Establishment of a Preoperative Predictive Model: A Retrospective Cohort Study with a Mean Follow-Up of 20 Months.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Does Antrum Size Matter in Sleeve Gastrectomy? Volume II-A Retrospective Multicentric Study with Long-Term Follow-Up.Journal of clinical medicine · 2024Article
- The Management of Biliary Disease in Patients with Severe Obesity Undergoing Metabolic and Bariatric Surgery-An International Expert Survey.Obesity surgery · 2024Article
- One Anastomosis Gastric Bypass vs. Sleeve Gastrectomy in the Remission of Type 2 Diabetes Mellitus: A Retrospective Analysis on 3 Years of Follow-Up.Journal of clinical medicine · 2024Article
- The role of bacteria in gallstone formation.Folia microbiologica · 2024Review
- Jejunal stenosis as a sequela after laparoscopic sleeve gastrectomy for morbid obesity: a case series.Updates in surgery · 2024Article
- Review
- Safety of concomitant cholecystectomy during one anastomosis gastric bypass compared with sleeve gastrectomy and Roux-en-Y gastric bypass.Updates in surgery · 2023Article
- Editorial: Clinical Updates on Bariatric Surgery.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBariatric surgery leads to rapid weight loss, a well-known risk factor for gallstone formation. Postoperative biliary complication rate requiring cholecystectomy is between 0.9 and 7.5% after laparoscopic sleeve gastrectomy and between 6 and 50% after laparoscopic gastric bypass. Several authors recommended ursodeoxycholic acid (UDCA) administration to reduce gallstone formation after diet-induced weight reduction. The aim of this randomized monocentric study is to evaluate gallstone incidence after prophylactic administration of UDCA in patients undergoing one anastomosis gastric bypass (OAGB).
methodsPatients undergoing OAGB were prospectively randomized into 2 groups: the UDCA group receiving oral UDCA 600 mg/days for 6 months in the immediate postoperative days, and the control group not administered with UDCA. Each group included 95 patients. Abdominal ultrasound, clinical evaluation, and quality of life scoring with Gastrointestinal Quality of Life Index (GIQLI) were performed postoperatively in all patients at 3, 6, and 12 months.
resultsAt 12 months of postoperative follow-up, 4 (4.2%) and 24 patients (25.2%) showed gallstones in the UDCA group and control group, respectively (p < 0.05). Among those who developed gallstones, 8 (28.6%) cases were symptomatic whereas 20 (71.4%) did not show any symptom. No statistically significant difference in GIQLI score between the two groups was found.
conclusionOAGB, as other malabsorbent procedures, appears to have higher rate of cholelithiasis than purely restrictive procedures. In our prospective randomized controlled study, a regular postoperative UDCA intake during the first 6 months seems to significantly reduce cholelithiasis incidence after OAGB, with no case of intolerance reported. Further studies are needed to assess this issue.
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