ArticlePediatric nephrology (Berlin, Germany)2021
Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy.
Article in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Kidney disease progression in pediatric and adult posterior urethral valves (PUV) patients.Pediatric nephrology (Berlin, Germany) · 2024Article
- Impact of Using Risk-Based Stratification on Referral of Patients With Chronic Kidney Disease From Primary Care to Specialist Care in the United Kingdom.Kidney international reports · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
backgroundObstructive uropathy (OU) is a leading cause of pediatric kidney injury. Accurate prediction of kidney disease progression may improve clinical outcomes. We aimed to examine discrimination and accuracy of a validated kidney failure risk equation (KFRE), previously developed in adults, in children with OU.
methodsWe identified 118 children with OU and an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m
resultsAmong the 118 children, 100 (85%) were boys, with median baseline age of 10 years (interquartile range, 6-14). Median eGFR was 42 mL/min/1.73m
conclusionsIn children with OU, the KFRE discriminated the 5-year risk of kidney failure at C statistic values lower than previously published in adults but comparable with suboptimal values reported in the overall CKiD population. The 8-variable equation did not improve model discrimination or accuracy, suggesting the need for continued research into additional, disease-specific markers.
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