Evidence map›Paper›PMID 32582882›Full record

ArticleOBM transplantation2020

Medawar's Paradox and Immune Mechanisms of Fetomaternal Tolerance.

Victoria Rendell, Natalie M Bath, Todd V Brennan

Abstract read
In one paragraph

Article in OBM transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Placenta in the Critically Ill Mother.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Article
  12. The impact of COVID-19 in pregnancy: Part II. Vaccination to pregnant women.Journal of the Chinese Medical Association : JCMA · 2021
    Review
  13. Review
  14. Review
  15. Editorial: Veterinary Reproductive Immunology.Frontiers in veterinary science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Victoria RendellDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Natalie M BathDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Todd V BrennanDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Funding

University of Wisconsin Transplant Reseach Training ProgramT32AI125231 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KAUFMAN, DIXON B · 2016 to 2020
$1.2M
Role of Endogenous Toll-Like Receptor Ligands in Allospecific T Cell ActivationK08AI101263 · NIAID · DUKE UNIVERSITY · PI BRENNAN, TODD VICTOR · 2012 to 2016
$644k
Direct Radiologic-Pathologic Correlation of Colorectal Liver Metastases with MR-Compatible Sectioning and Localization DeviceF32CA232352 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI RENDELL, VICTORIA · 2018 to 2018
$59k
NCI NIH HHS F32 CA232352NIAID NIH HHS K08 AI101263NIAID NIH HHS L30 AI090991NIAID NIH HHS T32 AI125231
6 · The paper itself

Abstract

Brazilian-born British biologist Dr. Peter Medawar played an integral role in developing the concepts of immunologic rejection and tolerance, which led to him receiving the Nobel Prize "for the discovery of acquired immunologic tolerance" and eventually made organ transplantation a reality. However, at the time of his early work in tolerance, a paradox to his theories was brought to his attention; how was pregnancy possible? Pregnancy resembles organ transplantation in that the fetus, possessing paternal antigens, is a semi-allogeneic graft that can survive without immunosuppression for 9 months. To answer this question, Medawar proposed three hypotheses of how a mother supports her fetus

Indexed as

fetomaternal toleranceimmune toleranceMedawar’s paradoxreproductive immunology

Identifiers

PMID32582882
PMCPMC7314236

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.