ArticlePhysics and imaging in radiation oncology2020
Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy.
Article in Physics and imaging in radiation oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Quantifying the Effect of 4-Dimensional Computed Tomography-Based Deformable Dose Accumulation on Representing Radiation Damage for Patients with Locally Advanced Non-Small Cell Lung Cancer Treated with Standard-Fractionated Intensity-Modulated Radiation Therapy.International journal of radiation oncology, biology, physics · 2024Trial
- Accumulated dose on daily iCBCT for rectal cancer: Effects of inter-fraction bowel cavity motion volume.Journal of applied clinical medical physics · 2026Article
- Associations of static anatomical geometry with planned dosimetric endpoints in prostate radiotherapy: a multicenter study.Frontiers in oncology · 2026Article
- Tumor-conditioned inter-patient registration using planning computed tomography for voxel-based analysis to predict radiation pneumonitis in lung cancer patients.Physics and imaging in radiation oncology · 2026Article
- Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Voxel-Based Dose-Toxicity Modeling for Predicting Post-Radiotherapy Toxicity: A Critical Perspective.Journal of clinical medicine · 2025Article
- Identifying the optimal time point for adaptive re-planning in prostate cancer radiotherapy to minimise rectal toxicity using normal tissue imaging biomarkers.Physics and imaging in radiation oncology · 2025Article
- Dose-response mapping of bladder and rectum in prostate cancer patients undergoing radiotherapy with and without baseline toxicity correction.Physics and imaging in radiation oncology · 2025Article
- Predictive Factors for Gastrointestinal and Genitourinary Toxicities in Prostate Cancer External Beam Radiotherapy: A Scoping Review.Diagnostics (Basel, Switzerland) · 2025Review
- Association of radiation-induced normal tissue toxicity with a high genetic risk for rheumatoid arthritis.Journal of the National Cancer Institute · 2025Article
- New rectum dose surface mapping methodology to identify rectal subregions associated with toxicities following prostate cancer radiotherapy.Physics and imaging in radiation oncology · 2025Article
- The use of dose surface maps as a tool to investigate spatial dose delivery accuracy for the rectum during prostate radiotherapy.Journal of applied clinical medical physics · 2024Article
- Impact of radiation dose distribution on nutritional supplementation needs in head and neck cancer radiotherapy: a voxel-based machine learning approach.Frontiers in oncology · 2024Article
- Selective sparing of bladder and rectum sub-regions in radiotherapy of prostate cancer combining knowledge-based automatic planning and multicriteria optimization.Physics and imaging in radiation oncology · 2023Article
- Predicting cancer relapse following lung stereotactic radiotherapy: an external validation study using real-world evidence.Frontiers in oncology · 2023Article
- Predictors for late genitourinary toxicity in men receiving radiotherapy for high-risk prostate cancer using planned and accumulated dose.Physics and imaging in radiation oncology · 2023Article
- Dose-volume analysis of planned versus accumulated dose as a predictor for late gastrointestinal toxicity in men receiving radiotherapy for high-risk prostate cancer.Physics and imaging in radiation oncology · 2022Article
- Estimating the percentage of patients who might benefit from proton beam therapy instead of X-ray radiotherapy.The British journal of radiology · 2022Article
- Radial Data Mining to Identify Density-Dose Interactions That Predict Distant Failure Following SABR.Frontiers in oncology · 2022Article
- Rectum Protection by Rectal Gel Injection in Cervical Cancer Brachytherapy: A Dosimetric StudyFrontiers in oncology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAssociations between dose and rectal toxicity in prostate radiotherapy are generally poorly understood. Evaluating spatial dose distributions to the rectal wall (RW) may lead to improvements in dose-toxicity modelling by incorporating geometric information, masked by dose-volume histograms. Furthermore, predictive power may be strengthened by incorporating the effects of interfraction motion into delivered dose calculations.Here we interrogate 3D dose distributions for patients with and without toxicity to identify rectal subregions at risk (SRR), and compare the discriminatory ability of planned and delivered dose. MATERIAL AND
methodsDaily delivered dose to the rectum was calculated using image guidance scans, and accumulated at the voxel level using biomechanical finite element modelling. SRRs were statistically determined for rectal bleeding, proctitis, faecal incontinence and stool frequency from a training set (n = 139), and tested on a validation set (n = 47).
resultsSRR patterns differed per endpoint. Analysing dose to SRRs improved discriminative ability with respect to the full RW for three of four endpoints. Training set AUC and OR analysis produced stronger toxicity associations from accumulated dose than planned dose. For rectal bleeding in particular, accumulated dose to the SRR (AUC 0.76) improved upon dose-toxicity associations derived from planned dose to the RW (AUC 0.63). However, validation results could not be considered significant.
conclusionsVoxel-level analysis of dose to the RW revealed SRRs associated with rectal toxicity, suggesting non-homogeneous intra-organ radiosensitivity. Incorporating spatial features of accumulated delivered dose improved dose-toxicity associations. This may be an important tool for adaptive radiotherapy in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.