ReviewFrontiers in cardiovascular medicine2020
Cerebrovascular Disease and Cognition in Chronic Kidney Disease Patients.
Review in Frontiers in cardiovascular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Association Between White Matter Hyperintensities and Chronic Kidney Disease: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Silent brain infarction is associated with executive dysfunction in community-dwelling older adults: the Sefuri-Yoshinogari study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Finerenone exposure and ischaemic stroke in patients with type 2 diabetes and chronic kidney disease: A propensity score-matched cohort study.Clinical medicine (London, England) · 2026Article
- Stroke risk factors and outcomes in Trinidad and Tobago: the START study.BMC neurology · 2026Observational
- Secular trends of incidence and prevalence of Parkinsonism subtypes: a cohort study in the United Kingdom.European journal of public health · 2026Article
- Chronic Kidney Disease Severity and Risk of Cognitive Impairment.JAMA network open · 2026Article
- Carotid pulsatile energy fraction surpasses traditional hemodynamic markers in explaining cognitive impairment among hemodialysis patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Hemodialysis versus peritoneal dialysis in elderly ESRD patients: a retrospective cohort study on survival and the role of comorbidities.BMC nephrology · 2026Article
- Elevated peak width of skeletonized mean diffusivity in patients with end-stage kidney disease: evidence of diffuse white matter microstructural injury.Frontiers in neurology · 2026Article
- Structural brain changes, cerebral oxygenation, and cognitive function in hemodialysis patients: a cross-sectional study.Frontiers in medicine · 2026Article
- Article
- The OsteoSense Imaging Agent Identifies Organ-Specific Patterns of Soft Tissue Calcification in an Adenine-Induced Chronic Kidney Disease Mouse Model.International journal of molecular sciences · 2025Article
- Role of Peripheral NLRP3 Inflammasome in Cognitive Impairments: Insights of Non-central Factors.Molecular neurobiology · 2025Review
- Early smoking and its impact on cardio-cerebrovascular diseases in patients with chronic kidney disease: a nationwide population-based study.BMC public health · 2025Article
- The impact of chronic kidney disease on prognosis in acute stroke: unraveling the pathophysiology and clinical complexity for optimal management.Clinical and experimental nephrology · 2025Review
- Cerebral white matter damage in patients with end-stage kidney disease associates with cognitive impairment.Clinical kidney journal · 2025Article
- Research progress on the kidney-gut-brain axis in brain dysfunction in maintenance hemodialysis patients.Frontiers in medicine · 2025Review
- Chronic kidney disease as a catalyst for cerebral microbleeds: understanding the underlying mechanisms and treatment approaches.Frontiers in medicine · 2025Review
- Interventions to improve cognitive performance in chronic kidney disease: A scoping review.PloS one · 2025Article
- The Impact of Plasma Homocysteine Level and Estimated Glomerular Filtration Rate on Neurological Function at Admission in Patients with Acute Ischemic Stroke: A Retrospective Cross-Sectional Study.Neuropsychiatric disease and treatment · 2025Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic kidney disease (CKD) affects both brain structure and function. Patients with CKD have a higher risk of both ischemic and hemorrhagic strokes. Age, prior disease history, hypertension, diabetes, atrial fibrillation, smoking, diet, obesity, and sedimentary lifestyle are most common risk factors. Renal-specific pathophysiologic derangements, such as oxidative stress, chronic inflammation, endothelial dysfunction, vascular calcification, anemia, gut dysbiosis, and uremic toxins are important mediators. Dialysis initiation constitutes the highest stroke risk period. CKD significantly worsens stroke outcomes. It is essential to understand the risks and benefits of established stroke therapeutics in patients with CKD, especially in those on dialysis. Subclinical cerebrovascular disease, such as of silent brain infarction, white matter lesions, cerebral microbleeds, and cerebral atrophy are more prevalent with declining renal function. This may lead to functional brain damage manifesting as cognitive impairment. Cognitive dysfunction has been linked to poor compliance with medications, and is associated with greater morbidity and mortality. Thus, understanding the interaction between renal impairment and brain is important in to minimize the risk of neurologic injury in patients with CKD. This article reviews the link between chronic kidney disease and brain abnormalities associated with CKD in detail.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.