Evidence map›Paper›PMID 32582693›Full record

ArticleFrontiers in cell and developmental biology2020

Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy.

Heiner Kremer, Julian Gebauer, Susanne Elvers-Hornung, Stefanie Uhlig, Hans-Peter Hammes, Elena Beltramo, Lothar Steeb, Martin C Harmsen, Carsten Sticht, Harald Klueter and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Heiner KremerInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Julian GebauerInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Susanne Elvers-HornungInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Stefanie UhligInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Hans-Peter Hammes5th Medical Department, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Elena BeltramoDepartment of Medical Sciences, University of Turin, Turin, Italy.
Lothar SteebPeloBiotech GmbH, Martinsried, Germany.
Martin C HarmsenDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Carsten StichtCenter for Medical Research, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Harald KlueterInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Karen BiebackInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Agnese FioriInstitute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
University Medical Centre Mannheim · DEGerman Red Cross · DEHeidelberg University · DEUniversity Hospital Heidelberg · DEUniversity Medical Center Groningen · NLUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a frequent diabetes-associated complication. Pericyte dropout can cause increased vascular permeability and contribute to vascular occlusion. Adipose-derived stromal cells (ASC) have been suggested to replace pericytes and restore microvascular support as potential therapy of DR. In models of DR, ASC not only generated a cytoprotective and reparative environment by the secretion of trophic factors but also engrafted and integrated into the retina in a pericyte-like fashion. The aim of this study was to compare the pro-angiogenic features of human ASC and human retinal microvascular pericytes (HRMVPC)

Indexed as

angiogenesisangiopoietindiabetic retinopathyhuman adipose-derived stromal cellshuman retinal pericytesvascular–endothelial growth factor

Identifiers

PMID32582693
PMCPMC7295949
OpenAlexW3034752682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.