Evidence map›Paper›PMID 32582623›Full record

ArticleFrontiers in chemistry2020

Protein Encapsulation: A Nanocarrier Approach to the Fluorescence Imaging of an Enzyme-Based Biomarker.

Zhiyuan Jia, Hai-Hao Han, Adam C Sedgwick, George T Williams, Lauren Gwynne, James T Brewster, Steven D Bull, A Toby A Jenkins, Xiao-Peng He, Holger Schönherr and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Prevent or Cure-The Unprecedented Need for Self-Reporting Materials.Angewandte Chemie (International ed. in English) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Zhiyuan JiaDepartment of Chemistry and Biology, Physical Chemistry & Research Center of Micro- and Nanochemistry and Engineering (Cμ), University of Siegen, Siegen, Germany.
Hai-Hao HanKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
Adam C SedgwickDepartment of Chemistry, The University of Texas at Austin, Austin, TX, United States.
George T WilliamsDepartment of Chemistry, University of Bath, Bath, United Kingdom.
Lauren GwynneDepartment of Chemistry, University of Bath, Bath, United Kingdom.
James T BrewsterDepartment of Chemistry, The University of Texas at Austin, Austin, TX, United States.
Steven D BullDepartment of Chemistry, University of Bath, Bath, United Kingdom.
A Toby A JenkinsDepartment of Chemistry, University of Bath, Bath, United Kingdom.
Xiao-Peng HeKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
Holger SchönherrDepartment of Chemistry and Biology, Physical Chemistry & Research Center of Micro- and Nanochemistry and Engineering (Cμ), University of Siegen, Siegen, Germany.
Jonathan L SesslerDepartment of Chemistry, The University of Texas at Austin, Austin, TX, United States.
Tony D JamesDepartment of Chemistry, University of Bath, Bath, United Kingdom.
University of Bath · GBThe University of Texas at Austin · USEast China University of Science and Technology · CNUniversity of Siegen · DE

Funding

Receptor and Carriers for Coupled Ion TransportR01GM103790 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI SESSLER, JONATHAN L, WILLIAMS, ROBERT O. · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM103790
6 · The paper itself

Abstract

Here, we report a new pentafluoropropanamido rhodamine fluorescent probe (ACS-HNE) that allows for the selective detection of neutrophil elastase (NE). ACS-HNE displayed high sensitivity, with a low limit of detection (<5.3 nM), and excellent selectivity toward elastase over other relevant biological analytes and enzymes. The comparatively poor solubility and cell permeability of neat ACS-HNE was improved by creating an ACS-HNE-albumin complex; this approach allowed for improvements in the

Indexed as

BSA-based nanocarriercell imagingelastase detectionfluorescence imagingnanocarrier-based enzyme detection

Identifiers

PMID32582623
PMCPMC7283737
OpenAlexW3033393619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.