ArticleFrontiers in public health2020
Analysis of Epigenetic Age Predictors in Pain-Related Conditions.
Article in Frontiers in public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Shaping the future of geriatric chronic pain care: a research agenda for progress.Pain management · 2025Article
- The Role of Lifestyle Behaviors in Shaping the Relationship Between Chronic Pain and Epigenetic Age Acceleration: Evidence From NHANES 1998 to 2002.Journal of pain research · 2025Article
- Prevalence and Sociodemographic Correlates of Chronic Pain Among a Nationally Representative Sample of Older Adults in the United States.The journal of pain · 2024Article
- High-Impact Pain Is Associated With Epigenetic Aging Among Middle-Aged and Older Adults: Findings From the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- The Pace of Biological Aging Predicts Nonspecific Chronic Low Back Pain Severity.The journal of pain · 2024Article
- The Epigenetics of Migraine.International journal of molecular sciences · 2023Review
- FGF-21 and GDF-15 are increased in migraine and associated with the severity of migraine-related disability.The journal of headache and pain · 2023Article
- Within subject cross-tissue analyzes of epigenetic clocks in substance use disorder postmortem brain and blood.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2023Article
- Epigenetic age predictors in community-dwelling adults with high impact knee pain.Molecular pain · 2022Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain prevalence is high worldwide and increases at older ages. Signs of premature aging have been associated with chronic pain, but few studies have investigated aging biomarkers in pain-related conditions. A set of DNA methylation (DNAm)-based estimates of age, called "epigenetic clocks," has been proposed as biological measures of age-related adverse processes, morbidity, and mortality. The aim of this study is to assess if different pain-related phenotypes show alterations in DNAm age. In our analysis, we considered three cohorts for which whole-blood DNAm data were available: heat pain sensitivity (HPS), including 20 monozygotic twin pairs discordant for heat pain temperature threshold; fibromyalgia (FM), including 24 cases and 20 controls; and headache, including 22 chronic migraine and medication overuse headache patients (MOH), 18 episodic migraineurs (EM), and 13 healthy subjects. We used the Horvath's epigenetic age calculator to obtain DNAm-based estimates of epigenetic age, telomere length, levels of 7 proteins in plasma, number of smoked packs of cigarettes per year, and blood cell counts. We did not find differences in epigenetic age acceleration, calculated using five different epigenetic clocks, between subjects discordant for pain-related phenotypes. Twins with high HPS had increased CD8+ T cell counts (nominal
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