Evidence map›Paper›PMID 32582564›Full record

ArticleFrontiers in cellular and infection microbiology2020

High Levels of Oxidative Stress Create a Microenvironment That Significantly Decreases the Diversity of the Microbiota in Diabetic Chronic Wounds and Promotes Biofilm Formation.

Jane H Kim, Paul R Ruegger, Elyson Gavin Lebig, Samantha VanSchalkwyk, Daniel R Jeske, Ansel Hsiao, James Borneman, Manuela Martins-Green

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. The dual role of the microbiome in chronic wound management.Cell communication and signaling : CCS · 2026
    Review
  6. Biofilm-Responsive Nanoplatforms for Infected Wound Reconstruction.International journal of nanomedicine · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Novel probioticFrontiers in microbiology · 2025
    Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Antioxidants (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jane H KimMolecular, Cell and Systems Biology Department, University of California, Riverside, Riverside, CA, United States.
Paul R RueggerMicrobiology and Plant Pathology Department, University of California, Riverside, Riverside, CA, United States.
Elyson Gavin LebigMolecular, Cell and Systems Biology Department, University of California, Riverside, Riverside, CA, United States.
Samantha VanSchalkwykStatistics Department, University of California, Riverside, Riverside, CA, United States.
Daniel R JeskeStatistics Department, University of California, Riverside, Riverside, CA, United States.
Ansel HsiaoMicrobiology and Plant Pathology Department, University of California, Riverside, Riverside, CA, United States.
James BornemanMicrobiology and Plant Pathology Department, University of California, Riverside, Riverside, CA, United States.
Manuela Martins-GreenMolecular, Cell and Systems Biology Department, University of California, Riverside, Riverside, CA, United States.
University of California, Riverside · US

Funding

Gut microbiome-mediated small-molecule signaling and resistance to invading microorganismsR35GM124724 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HSIAO, ANSEL · 2017 to 2021
$1.8M
Microbiome Dynamics from Commensal to Biofilm-FormingR21AI138188 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BORNEMAN, JAMES, JESKE, DANIEL ROBERT · 2018 to 2019
$402k
NIAID NIH HHS R21 AI138188NIGMS NIH HHS R35 GM124724
6 · The paper itself

Abstract

Diabetics chronic wounds are characterized by high levels of oxidative stress (OS) and are often colonized by biofilm-forming bacteria that severely compromise healing and can result in amputation. However, little is known about the role of skin microbiota in wound healing and chronic wound development.

Indexed as

Diabetes MellitusMicrobiotaBiofilmsCorynebacteriumHumansOxidative StressPseudomonas aeruginosaStaphylococcusdysbiosisEnterobacter cloacaeimpaired healingprobioticsPseudomonas aeruginosaskin microbiomewound healingwound microbiome

Identifiers

PMID32582564
PMCPMC7283391
OpenAlexW3033475116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.