Evidence map›Paper›PMID 32582365›Full record

ReviewInfectious agents and cancer2020

Epstein-Barr virus BART microRNAs in EBV- associated Hodgkin lymphoma and gastric cancer.

Valli De Re, Laura Caggiari, Mariangela De Zorzi, Valentina Fanotto, Gianmaria Miolo, Fabio Puglisi, Renato Cannizzaro, Vincenzo Canzonieri, Agostino Steffan, Piero Farruggia and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Infectious agents and cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. The Role of Extracellular Vesicles in Epstein-Barr Virus Immunology and Pathogenesis for Possible Diagnostic and Therapeutic Direction.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
  11. Review
  12. Review
  13. Regulatory role of microRNAs in virus-mediated inflammation.Journal of inflammation (London, England) · 2024
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Research progress on the mechanism of exosome-mediated virus infection.Frontiers in cellular and infection microbiology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Valli De ReImmunopathology and Cancer Biomarkers, Department of Translational Research, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN Italy.ORCID 0000-0001-6100-9373
Laura CaggiariImmunopathology and Cancer Biomarkers, Department of Translational Research, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN Italy.
Mariangela De ZorziImmunopathology and Cancer Biomarkers, Department of Translational Research, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN Italy.
Valentina FanottoMedical Oncology and Cancer Prevention, Department of Medical Oncology, IRCCS, Centro di Riferimento Oncologico di Aviano (CRO), Aviano, PN Italy.
Gianmaria MioloMedical Oncology and Cancer Prevention, Department of Medical Oncology, IRCCS, Centro di Riferimento Oncologico di Aviano (CRO), Aviano, PN Italy.
Fabio PuglisiMedical Oncology and Cancer Prevention, Department of Medical Oncology, IRCCS, Centro di Riferimento Oncologico di Aviano (CRO), Aviano, PN Italy.
Renato CannizzaroGastroenterology, Department of Medical Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN Italy.
Vincenzo CanzonieriDepartment of Medical, Surgical and Health Sciences, University of Trieste Medical School, Trieste, Italy.
Agostino SteffanImmunopathology and Cancer Biomarkers, Department of Translational Research, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN Italy.
Piero FarruggiaPediatric Hematology and Oncology Unit, Oncology, Department, A.R.N.A.S. Ospedali Civico Di Cristina e Benfratelli, Palermo, PN Italy.
Egesta LopciNuclear Medicine Department, Humanitas Clinical and Research Hospital, Via Manzoni 56, 20089 Rozzano, MI Italy.
Emanuele S G d'AmoreDepartment of Pathology, San Bortolo Hospital, Vicenza, VI Italy.
Roberta BurnelliPediatric Hematology-Oncology, Azienda Ospedaliera Universitaria, Ospedale Sant'Anna, Ferrara, FE Italy.
Lara MussolinPediatric Hemato-Oncology Clinic, Department of Women's and Children's Health, University of Padua, Institute of Paediatric Research Fondazione Città della Speranza, Padua, PD Italy.
Maurizio MascarinPediatric Radiotherapy Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, PN Italy.
Centro di Riferimento Oncologico · ITAzienda di Rilievo Nazionale ed Alta Specializzazione · ITHumanitas University · ITOspedale San Bortolo · ITOspedale Sant'Anna · ITUniversity of Padua · ITUniversity of Trieste · ITUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEBV produces miRNAs with important functions in cancer growth, tumor invasion and host immune surveillance. The discovery of EBV miR-BARTs is recent, and most of their functions are still unknown. Nonetheless, some new studies underline their key roles in EBV-associated malignancies. MAIN BODY: In EBV-associated tumors, the expression profile of miR-BARTs varies according to the cell type, autophagic process and signals received from the tumor microenvironment. By the same way of interest is the interaction between tumor cells and the tumor environment by the release of selected EBV miR-BARTs in addition to the tumor proteins trough tumor exosomes.

conclusionIn this review, we discuss new findings regarding EBV miR-BARTs in Hodgkin lymphoma and gastric cancer. The recent discovery that miRNAs are released by exosomes, including miR-BARTs, highlights the importance of tumor and microenvironment interplay with more specific effects on the host immune response.

Indexed as

BamHI fragment a rightward transcriptEBVEpstein-Barr virus; miRNAGastric carcinoma cancerHLHodgkin lymphoma; GCMicro RNA; BART

Identifiers

PMID32582365
PMCPMC7310352
OpenAlexW3036848521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.