ArticleImmunity & ageing : I & A2020
In-depth immune cellular profiling reveals sex-specific associations with frailty.
Article in Immunity & ageing : I & A, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Influenza vaccine-specific CD4NPJ vaccines · 2026Article
- Physical frailty in relation to immunosenescence involving pDC function in the Japanese elderly: a cross-sectional survey study.Immunity & ageing : I & A · 2026Article
- Impaired function of Vγ9Vδ2 T cells in frail elderly.Immunity & ageing : I & A · 2026Article
- Clinical, functional, and immunological profiles across frailty subgroups in maintenance hemodialysis patient.Frontiers in endocrinology · 2026Observational
- Ageing, immune fitness and cancer.Nature reviews. Cancer · 2025Review
- Pre-Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness.Aging cell · 2025Article
- Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice.GeroScience · 2025Article
- Applying a life course approach to elucidate the biology of sex differences in frailty: early-life gonadectomy diminishes late-life robustness in male and female dogs in the Exceptional Aging in Rottweilers Study.Biology of sex differences · 2025Article
- Prevalence and determinants of multidimensional frailty in hospitalized older adults with coronary heart disease: a LASSO regression analysis.Frontiers in cardiovascular medicine · 2025Article
- Elucidating the causal nexus and immune mediation between frailty and chronic kidney disease: integrative multi-omics analysis.Renal failure · 2024Article
- Inflammatory markers and frailty in home-dwelling elderly, a cross-sectional study.BMC geriatrics · 2024Article
- Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years.Biology of sex differences · 2023Article
- Cytomegalovirus and Epstein-Barr virus co-infected young and middle-aged adults can have an aging-related T-cell phenotype.Scientific reports · 2023Article
- Sex- and age-specific aspects of human peripheral T-cell dynamics.Frontiers in immunology · 2023Article
- Causal Association of Cardiac Function by Magnetic Resonance Imaging with Frailty Index: A Mendelian Randomization Study.Phenomics (Cham, Switzerland) · 2022Article
- Identification of aging-associated immunotypes and immune stability as indicators of post-vaccination immune activation.Aging cell · 2022Article
- Sex-specific transcriptome differences in a middle-aged frailty cohort.BMC geriatrics · 2022Article
- Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly.Immunity & ageing : I & A · 2022Article
- Inflammatory marker trajectories associated with frailty and ageing in a 20-year longitudinal study.Clinical & translational immunology · 2022Article
- Clustering Inflammatory Markers with Sociodemographic and Clinical Characteristics of Patients with Diabetes Type 2 Can Support Family Physicians' Clinical Reasoning by Reducing Patients' Complexity.Healthcare (Basel, Switzerland) · 2021Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith advancing age, the composition of leukocyte subpopulations in peripheral blood is known to change, but how this change differs between men and women and how it relates to frailty is poorly understood. Our aim in this exploratory study was to investigate whether frailty is associated with changes in immune cell subpopulations and whether this differs between men and women. Therefore, we performed in-depth immune cellular profiling by enumerating a total of 37 subpopulations of T cells, B cells, NK cells, monocytes, and neutrophils in peripheral blood of 289 elderly people between 60-87 years of age. Associations between frailty and each immune cell subpopulation were tested separately in men and women and were adjusted for age and CMV serostatus. In addition, a random forest algorithm was used to predict a participant's frailty score based on enumeration of immune cell subpopulations.
resultsIn the association study, frailty was found to be associated with increased numbers of neutrophils in both men and in women. Frailer women, but not men, showed higher numbers of total and CD16
conclusionsIn-depth immune cellular profiling revealed consistent associations of frailty with elevated numbers of myeloid cell subpopulations in both men and women. Furthermore, additional associations were found between frailty and lower numbers of some T cell subpopulations, in women only. Thus, our study indicates sex-specific associations of immune subpopulations with frailty. We hope that our study will prompt further investigation into the sex-specific immune mechanisms associated with the development of frailty.
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