Evidence map›Paper›PMID 32582164›Full record

ArticleFrontiers in immunology2020

Adjuvanting Allergen Extracts for Sublingual Immunotherapy: Calcitriol Downregulates CXCL8 Production in Primary Sublingual Epithelial Cells.

Michael P Pelst, Clara Höbart, Charlotte Wallaeys, Hilde De Rooster, Yannick Gansemans, Filip Van Nieuwerburgh, Bert Devriendt, Eric Cox

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Michael P PelstLaboratory of Immunology, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Clara HöbartCenter of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Charlotte WallaeysVIB Center for Inflammation Research, Ghent, Belgium.
Hilde De RoosterSmall Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Yannick GansemansLaboratory for Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
Filip Van NieuwerburghLaboratory for Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
Bert DevriendtLaboratory of Immunology, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Eric CoxLaboratory of Immunology, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Ghent University · BEMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Application of allergens onto the sublingual epithelium is used to desensitize allergic individuals, a treatment known as sublingual immunotherapy. However, the response of sublingual epithelial cells to house dust mite allergen and potential tolerance-promoting adjuvants such as Toll-like receptor (TLR) ligands and calcitriol has not been investigated. In order to study this, primary sublingual epithelial cells were isolated from dogs and cultured

Indexed as

Adjuvants, ImmunologicAllergensAnimalsAntigens, DermatophagoidesCalcitriolCells, CulturedDermatophagoides farinaeDogsEpithelial CellsGene ExpressionInterleukin-8LigandsModels, AnimalMouth MucosaProstaglandin-E SynthasesReceptors, GlucocorticoidAdjuvants, ImmunologicAllergensAntigens, DermatophagoidesCalcitriolInterleukin-8LigandsProstaglandin-E SynthasesReceptors, GlucocorticoidRNA, MessengerToll-Like ReceptorscalcitriolCXCL8Dermatophagoides farinaedogepitheliumsublingualsublingual immunotherapyToll-like receptor

Identifiers

PMID32582164
PMCPMC7295906
OpenAlexW3034800071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.