SynthesisFrontiers in immunology2020
Association of Histological and Clinical Chorioamnionitis With Neonatal Sepsis Among Preterm Infants: A Systematic Review, Meta-Analysis, and Meta-Regression.
Synthesis in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- The effect of intrapartum maternal fever on neonatal outcomes: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Association between Endotype of Prematurity and Mortality: A Systematic Review, Meta-Analysis, and Meta-Regression.Neonatology · 2023Pooled it
- Association of Chorioamnionitis with Early and Late Neonatal Sepsis in Preterm Infants with Gestational Age < 32 Weeks.Diagnostics (Basel, Switzerland) · 2026Article
- Histologic chorioamnionitis and fat mass accretion in infants born preterm.Pediatric research · 2026Article
- Prevalence and risk factors for neonatal sepsis among very preterm infants in China: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Machine learning for prediction of histologic chorioamnionitis (stage ≥II) in parturients receiving labor analgesia: a retrospective multicentre cohort study.Frontiers in medicine · 2026Article
- The utility of C-reactive protein in neonatal early-onset sepsis screening: A territory-wide cohort analysis.Pediatric investigation · 2025Article
- Predicting Neonatal Morbidity and Correlations with Maternal and Neonatal Biomarkers in Connection with Fetal Inflammatory Response Syndrome in Premature Births.Journal of clinical medicine · 2025Article
- Association Between Endotype of Prematurity and Cystic Periventricular Leukomalacia: A Bayesian Model-Averaged Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Zigzag Fetal Heart Rate Pattern in an Uncomplicated Pregnancy with Dual Intrauterine Infection Detected During Labor with Intact Membranes: A Case Report.Healthcare (Basel, Switzerland) · 2025Article
- Intrauterine inflammation exposure may increase the risk of late-onset sepsis in premature infants: a retrospective cohort study.Italian journal of pediatrics · 2025Article
- Infection-Related Preterm Birth.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Review
- Effect of chorioamnionitis on postnatal growth in very preterm infants: a population-based study in Japan.Archives of gynecology and obstetrics · 2025Article
- Histological chorioamnionitis and its predictors among mothers with premature rupture of membranes delivering at tertiary hospitals in Uganda: a multicenter cross-sectional study.BMC pregnancy and childbirth · 2025Article
- Implementation of an EOS calculator-based protocol decreased infant antibiotic exposure in chorioamnionitis without correlation with placental histopathology.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- Risk Factors for Histologic Chorioamnionitis Among Women with Prenatal Fever During Preterm Delivery: A Retrospective Cohort Study.International journal of women's health · 2025Article
- [Advances in clinical management of neonatal sepsis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Does perinatal management have the potential to reduce the risk of intraventricular hemorrhage in preterm infants?Frontiers in pediatrics · 2024Article
- Risk of adverse perinatal outcomes among women with clinical and subclinical histopathological chorioamnionitis.Frontiers in medicine · 2024Article
- Chorioamnionitis-exposure alters serum cytokine trends in premature neonates.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chorioamnionitis (CA) is considered a key risk factor for very preterm birth and for developing early onset sepsis (EOS) in preterm infants, but recent data suggest that CA might be protective against late onset sepsis (LOS). We performed a systematic review and meta-analysis of studies exploring the association between CA and sepsis. A comprehensive literature search was performed in PubMed/MEDLINE and EMBASE, from their inception to December 1, 2018. A random-effects model was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Sources of heterogeneity were analyzed by subgroup and meta-regression analyses. The following categories of sepsis were analyzed: EOS, LOS, unspecified onset sepsis (UOS), culture-proven, and clinical sepsis. CA was subdivided into clinical and histological chorioamnionitis. Funisitis was also analyzed. We found 3,768 potentially relevant studies, of which 107 met the inclusion criteria (387,321 infants; 44,414 cases of CA). Meta-analysis showed an association between any CA and any EOS (OR 4.29, CI 3.63-5.06), any LOS (OR 1.29, CI 1.11-1.54), and any UOS (OR 1.59, CI 1.11-1.54). Subgroup analysis showed that CA was associated with culture-proven EOS (OR 4.69, CI 3.91-5.56), clinical EOS (OR 3.58, CI 1.90-6.76), and culture-proven LOS (OR 1.31, CI 1.12-1.53), but not with clinical LOS (OR 1.52, CI 0.78-2.96). The presence of funisitis did not increase the risk of either EOS or LOS when compared with CA without funisitis. CA-exposed infants had lower gestational age (-1.11 weeks, CI -1.37 to -0.84) than the infants not exposed to CA. Meta-regression analysis showed that the lower gestational age of the CA group correlated with the association between CA and LOS but not with the association between CA and EOS. In conclusion, our data suggest that the positive association between chorioamnionitis and LOS may be modulated by the effect of chorioamnionitis on gestational age.
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