ArticleFrontiers in microbiology2020
An Invertebrate Burn Wound Model That Recapitulates the Hallmarks of Burn Trauma and Infection Seen in Mammalian Models.
Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 44 citations in OpenAlex.
- The use of Galleria mellonella to study microbial interactions, immune responses, and substrate interactions.Essays in biochemistry · 2026Review
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- Tyrosine-capped gold nanoparticles enable cysteine-free peptide loading, enhancing the antipseudomonal efficacy of scorpion-derived AamAP1-Lys-NHJournal of materials chemistry. B · 2026Article
- From Natural Product to Topical Antimicrobial Candidate: EvaluatingPharmaceuticals (Basel, Switzerland) · 2026Article
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- Current Overview and Main Challenges of the Use of Galleria mellonella in Biomedical Research.Current protocols · 2026Review
- Lignin Nanoparticles Containing Cobalt-Cyanine Complexes: Potential Multifunctional Platforms for Photoacoustic Imaging and Photothermal Treatment of Bacterial Biofilms in Chronic Wounds.Macromolecular bioscience · 2026Article
- Development of a Methylene Blue Carrier System in Gellan Gum for Application in Antimicrobial Photodynamic Therapy againstACS omega · 2025Article
- Uncovering the antifungal potential of Cannabidiol and Cannabidivarin.PLoS neglected tropical diseases · 2025Article
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- Galleria mellonella as a drug discovery model to study oxidative stress.Scientific reports · 2025Article
- Hydrogel Containing Biogenic Silver Nanoparticles andPharmaceutics · 2025Article
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- Nanoparticle-induced systemic toxicity and immune response inFrontiers in pharmacology · 2025Article
- Carbon source competition within the wound microenvironment can significantly influence infection progression.NPJ biofilms and microbiomes · 2024Article
- Human breast milk isolated lactic acid bacteria: antimicrobial and immunomodulatory activity on theFrontiers in cellular and infection microbiology · 2024Article
- Investigating Secretion Systems and Effectors on Galleria mellonella.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Using theMicrobiology (Reading, England) · 2023Article
- The VirtuousAntibiotics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The primary reason for skin graft failure and the mortality of burn wound patients, particularly those in burn intensive care centers, is bacterial infection. Several animal models exist to study burn wound pathogens. The most commonly used model is the mouse, which can be used to study virulence determinants and pathogenicity of a wide range of clinically relevant burn wound pathogens. However, animal models of burn wound pathogenicity are governed by strict ethical guidelines and hindered by high levels of animal suffering and the high level of training that is required to achieve consistent reproducible results. In this study, we describe for the first time an invertebrate model of burn trauma and concomitant wound infection. We demonstrate that this model recapitulates many of the hallmarks of burn trauma and wound infection seen in mammalian models and in human patients. We outline how this model can be used to discriminate between high and low pathogenicity strains of two of the most common burn wound colonizers
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