ArticleFrontiers in neurology2020
Quantitative Evaluation of a New Posturo-Locomotor Phenotype in a Rodent Model of Acute Unilateral Vestibulopathy.
Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy.CNS neuroscience & therapeutics · 2026Article
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- Coniferaldehyde reverses 3-nitropropionic acid-induced Huntington's disease pathologies via PKM2 restoration and JAK2/STAT3 inhibition.Molecular medicine (Cambridge, Mass.) · 2025Article
- Effects of inter-individual variability in experimenters' sensitivity and training on behavioral assessment of animal models of vestibular disorders.Frontiers in neurology · 2025Article
- An open-source tool for automated human-level circling behavior detection.Scientific reports · 2024Article
- Sensory feedback and central neuronal interactions in mouse locomotion.Royal Society open science · 2024Article
- The Vestibular Nuclei: A Cerebral Reservoir of Stem Cells Involved in Balance Function in Normal and Pathological Conditions.International journal of molecular sciences · 2024Review
- Sensory Feedback and Central Neuronal Interactions in Mouse Locomotion.bioRxiv : the preprint server for biology · 2023Article
- Cellular and Molecular Mechanisms of Vestibular Ageing.Journal of clinical medicine · 2023Review
- Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology.International journal of molecular sciences · 2023Review
- An Open-Source Tool for Automated Human-Level Circling Behavior Detection.bioRxiv : the preprint server for biology · 2023Article
- Chronic motor performance following different traumatic brain injury severity-A systematic review.Frontiers in neurology · 2023Review
- Dose- and application route-dependent effects of betahistine on behavioral recovery and neuroplasticity after acute unilateral labyrinthectomy in rats.Frontiers in neurology · 2023Article
- An integrated workflow for 2D and 3D posture analysis during vestibular system testing in mice.Frontiers in neurology · 2023Article
- Oxytocin Disturbs Vestibular Compensation and Modifies Behavioral Strategies in a Rodent Model of Acute Vestibulopathy.International journal of molecular sciences · 2022Article
- What Predictability for Animal Models of Peripheral Vestibular Disorders?Biomedicines · 2022Review
- Article
- Effect of Fluoxetine and Acacetin on Central Vestibular Compensation in an Animal Model of Unilateral Peripheral Vestibulopathy.Biomedicines · 2022Article
- Article
- Vertigoheel improves central vestibular compensation after unilateral peripheral vestibulopathy in rats.Frontiers in neurology · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vestibular pathologies are difficult to diagnose. Existing devices make it possible to quantify and follow the evolution of posturo-locomotor symptoms following vestibular loss in static conditions. However, today, there are no diagnostic tools allowing the quantitative and spontaneous analysis of these symptoms in dynamic situations. With this in mind, we used an open-field video tracking test aiming at identifying specific posturo-locomotor markers in a rodent model of vestibular pathology. Using Ethovision XT 14 software (Noldus), we identified and quantified several behavioral parameters typical of unilateral vestibular lesions in a rat model of vestibular pathology. The unilateral vestibular neurectomy (UVN) rat model reproduces the symptoms of acute unilateral peripheral vestibulopathy in humans. Our data show deficits in locomotion velocity, distance traveled and animal mobility in the first day after the injury. We also highlighted alterations in several parameters, such as head and body acceleration, locomotor pattern, and position of the body, as well as "circling" behavior after vestibular loss. Here, we provide an enriched posturo-locomotor phenotype specific to full and irreversible unilateral vestibular loss. This test helps to strengthen the quantitative evaluation of vestibular disorders in unilateral vestibular lesion rat model. It may also be useful for testing pharmacological compounds promoting the restoration of balance. Transfer of these novel evaluation parameters to human pathology may improve the diagnosis of acute unilateral vestibulopathies and could better follow the evolution of the symptoms upon pharmacological and physical rehabilitation.
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