ReviewFrontiers in neurology2020
Psychogenic Non-epileptic Seizures and Pseudo-Refractory Epilepsy, a Management Challenge.
Review in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- The neurobiology of functional neurological disorders characterised by impaired awareness.Frontiers in psychiatry · 2023Pooled it
- Treatment of Functional Neurological Disorders.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Surprising epileptic semiology in seventeenth-century beatification testimonies: A neuropsychiatric analysis of St. Joseph of Copertino.Epilepsy & behavior reports · 2026Article
- Article
- Pupillary Dilation in an Adolescent With Psychogenic Non-epileptic Seizures: A Case Report.Cureus · 2026Article
- Hemorrhage Accompanying Psychogenic Nonepileptic Seizure During Cesarean Section: A Case Report.International journal of women's health · 2026Article
- Epilepsy in children and young people as a stigma throughout history: identifying cultural, religious and educational factors to design strategies for contemporary social inclusion.Frontiers in neurology · 2026Review
- Unraveling functional neurological disorder in pediatric populations: A systematic review of diagnosis, treatment, and outcomes.World journal of clinical pediatrics · 2025Article
- Dissociative seizures mimicking epileptic seizures: diagnostic challenges in a case with atypical eye movements.Acta epileptologica · 2025Article
- "Resistance Is Futile": A Pilot Study into Pseudoresistance in Canine Epilepsy.Animals : an open access journal from MDPI · 2023Article
- Content or context? A study protocol for a three-arm parallel randomised controlled trial of RBMJ open · 2023Article
- Functional Neurologic Disorders, disorders to be managed by neurologists, or are neurologists wandering in a dangerous field with inadequate resources?Frontiers in psychiatry · 2023Review
- A systems biology approach for discovering the cellular and molecular aspects of psychogenic non-epileptic seizure.Frontiers in psychiatry · 2023Article
- Clinical manifestations and cultural correlates of psychogenic nonepileptic seizure symptoms: An Indian perspective.Journal of family medicine and primary care · 2022Article
- Prevalence and risk factors of functional seizures among adult Sudanese patients with epilepsy, a cross-sectional clinic-based study.Annals of medicine and surgery (2012) · 2022Article
- Cognitive Impairment in People with Epilepsy.Journal of clinical medicine · 2022Review
- Article
- Bipolar spectrum disorders in neurologic disorders.Frontiers in psychiatry · 2022Review
- FALSE PHARMACORESISTANCE - A TRUE PROBLEM.Acta clinica Croatica · 2021Review
- Patients With Epilepsy Who Underwent Epilepsy Surgery During the COVID-19 Pandemic Showed Less Depressive Tendencies.Frontiers in neurology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychogenic nonepileptic seizures (PNES) are neurobehavioral conditions positioned in a gray zone, not infrequently a no-man land, that lies in the intersection between Neurology and Psychiatry. According to the DSM 5, PNES are a subgroup of conversion disorders (CD), while the ICD 10 classifies PNES as dissociative disorders. The incidence of PNES is estimated to be in the range of 1.4-4.9/100,000/year, and the prevalence range is between 2 and 33 per 100,000. The International League Against Epilepsy (ILAE) has identified PNES as one of the 10 most critical neuropsychiatric conditions associated with epilepsy. Comorbidity between epilepsy and PNES, a condition leading to "dual diagnosis," is a serious diagnostic and therapeutic challenge for clinicians. The lack of prompt identification of PNES in epileptic patients can lead to potentially harmful increases in the dosage of anti-seizure drugs (ASD) as well as erroneous diagnoses of refractory epilepsy. Hence, pseudo-refractory epilepsy is the other critical side of the PNES coin as one out of four to five patients admitted to video-EEG monitoring units with a diagnosis of pharmaco-resistant epilepsy is later found to suffer from non-epileptic events. The majority of these events are of psychogenic origin. Thus, the diagnostic differentiation between pseudo and true refractory epilepsy is essential to prevent actions that lead to unnecessary treatments and ASD-related side effects as well as produce a negative impact on the patient's quality of life. In this article, we review and discuss recent evidence related to the neurobiology of PNES. We also provide an overview of the classifications and diagnostic steps that are employed in PNES management and dwell on the concept of pseudo-resistant epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.