ReviewFrontiers in physiology2020
Theoretical Bases for the Role of Red Blood Cell Shape in the Regulation of Its Volume.
Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease-related dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Review
- Membrane Localization of Piezo1 in the Context of Its Role in the Regulation of Red Blood Cell Volume.Frontiers in physiology · 2022Article
- Hereditary Xerocytosis: Differential Behavior of PIEZO1 Mutations in the N-Terminal Extracellular Domain Between Red Blood Cells and HEK Cells.Frontiers in physiology · 2021Article
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1 author at 1 institution in 1 country.
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Abstract
The red blood cell (RBC) membrane contains a mechanosensitive cation channel Piezo1 that is involved in RBC volume homeostasis. In a recent model of the mechanism of its action it was proposed that Piezo1 cation permeability responds to changes of the RBC shape. The aim here is to review in a descriptive manner different previous studies of RBC behavior that formed the basis for this proposal. These studies include the interpretation of RBC and vesicle shapes based on the minimization of membrane bending energy, the analyses of various consequences of compositional and structural features of RBC membrane, in particular of its membrane skeleton and its integral membrane proteins, and the modeling of the establishment of RBC volume. The proposed model of Piezo1 action is critically evaluated, and a perspective presented for solving some remaining experimental and theoretical problems. Part of the discussion is devoted to the usefulness of theoretical modeling in studies of the behavior of cell systems in general.
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