ArticleFrontiers in pharmacology2020
Mining Sudanese Medicinal Plants for Antiprotozoal Agents.
Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Mulinane- and Azorellane-Type Diterpenoids: A Systematic Review of Their Biosynthesis, Chemistry, and Pharmacology.Biomolecules · 2020Pooled it
- Repurposing of Inhibitors of Plasmodial Aspartate Transcarbamoylase Toward Trypanosoma Cruzi.ChemMedChem · 2026Article
- Dissecting Structural Requirements of Leucinostatin A Derivatives for Antiprotozoal Activity and Mammalian Toxicity.Journal of medicinal chemistry · 2025Article
- Venturicidin A affects the mitochondrial membrane potential and induces kDNA loss inAntimicrobial agents and chemotherapy · 2024Article
- Antiprotozoal Activity of Plants Used in the Management of Sleeping Sickness in Angola and Bioactivity-Guided Fractionation ofMolecules (Basel, Switzerland) · 2024Article
- New myxobacteria of theMicrobiology spectrum · 2024Article
- Article
- Phytochemical Screening, GC-MS Analysis, and Evaluating In Vivo Antitrypanosomal Effects of a Methanolic Extract ofAntibiotics (Basel, Switzerland) · 2023Article
- Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity ofAdvances in pharmacological and pharmaceutical sciences · 2022Review
- AntiprotozoalAntibiotics (Basel, Switzerland) · 2021Article
- Lignans, Amides, and Saponins fromMolecules (Basel, Switzerland) · 2020Article
- HPLC-Based Activity Profiling for Antiprotozoal Compounds inFrontiers in pharmacology · 2020Article
- Evaluation of Antimalarial Activity of Ethanolic Extract ofJournal of evidence-based integrative medicineArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neglected tropical diseases are major health hazards in developing countries. Annually, up to 30 million people are affected by either Chagas disease, African trypansomiasis or leishmaniasis, and more than 200 million by malaria. Most of the currently available drugs have drawbacks in terms of toxicity, limited oral availability, development of resistance, or non-affordability. Tropical plants of the arid zones are a treasure chest for the discovery of bioactive secondary metabolites. This study aims to compile Sudanese medicinal plants, validate their antiprotozoal activities, and identify active molecules. We have performed a survey of medicinal plants of Sudan and selected 62 that are being used in Sudanese traditional medicine. From these, we collected materials such as leaves, stem, bark, or fruit. The plant materials were extracted in 70% ethanol and further fractionated by liquid-liquid partitioning using solvents of increasing polarity. This resulted in a library of 235 fractions. The library was tested
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