Evidence map›Paper›PMID 32581770›Full record

ArticleFrontiers in aging neuroscience2020

Serum Uric Acid, Alzheimer-Related Brain Changes, and Cognitive Impairment.

Jee Wook Kim, Min Soo Byun, Dahyun Yi, Jun Ho Lee, So Yeon Jeon, Kang Ko, Gijung Jung, Han Na Lee, Jun-Young Lee, Chul-Ho Sohn and 5 more

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In one paragraph

Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jee Wook KimDepartment of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, South Korea.
Min Soo ByunInstitute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, South Korea.
Dahyun YiInstitute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, South Korea.
Jun Ho LeeDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
So Yeon JeonDepartment of Neuropsychiatry, Chungnam National University Hospital, Daejeon, South Korea.
Kang KoDepartment of Geriatric Psychiatry, National Center for Mental Health, Seoul, South Korea.
Gijung JungDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
Han Na LeeDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea.
Jun-Young LeeDepartment of Neuropsychiatry, SMG-SNU Boramae Medical Center, Seoul, South Korea.
Chul-Ho SohnDepartment of Radiology, Seoul National University Hospital, Seoul, South Korea.
Yun-Sang LeeDepartment of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Seong A ShinDepartment of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea.
Yu Kyeong KimDepartment of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea.
Dong Young LeeInstitute of Human Behavioral Medicine, Medical Research Center Seoul National University, Seoul, South Korea.
KBASE Research Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite known associations of lower serum uric acid (UA) with Alzheimer's disease (AD) dementia or AD-related cognitive impairment, little is known regarding the underlying patho-mechanisms. We aimed to examine the relationships of serum UA with in vivo AD pathologies including cerebral beta-amyloid (Aβ) and tau deposition, AD-signature region cerebral glucose metabolism (AD-CM), and white matter hyperintensities (WMH). We also investigated the association between serum UA and cognitive performance, and then assessed whether such an association is mediated by the brain pathologies.

methodsA total of 430 non-demented older adults underwent comprehensive clinical assessments, measurement of serum UA level, and multimodal brain imaging, including Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, fluorodeoxyglucose (FDG)-PET, and magnetic resonance imaging scans. Mini-Mental State Examination (MMSE) and word list recall (WLR) test scores were used to measure cognitive performance.

resultsSerum UA level was significantly associated with AD-CM, but not with Aβ deposition, tau deposition, or WMH volume. Serum UA levels also had significant association with WLR and marginal association with MMSE; such associations disappeared when AD-CM was controlled as a covariate, indicating that AD-CM has a mediating effect.

conclusionThe findings of the present study indicate that there is an association of low serum UA with AD-related cerebral hypometabolism, and whether this represents a causal relationship remains to be determined.

Indexed as

Alzheimer’s diseasecerebral glucose metabolismcognitive impairmentneurodegenerationserum uric acid

Identifiers

PMID32581770
PMCPMC7291838

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.