ArticleFrontiers in aging neuroscience2020
Multiparity, Brain Atrophy, and Cognitive Decline.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024Guideline
- Effect of Parity and β-Amyloid on Cognition and Hippocampal Volume in Postmenopausal Women.Neurology · 2026Article
- The effects of a second pregnancy on women's brain structure and function.Nature communications · 2026Article
- Reproductive factors and brain volume in community-dwelling individuals: the Ohasama Study.Environmental health and preventive medicine · 2026Article
- Fat mass in postmenopausal women with osteoporosis is associated with cognitive function.Scientific reports · 2025Article
- Association of menarche, menopause, and reproductive history with cognitive performance in older US women: a cross-sectional study from NHANES 2011-2014.BMC public health · 2025Article
- Number of children and risk of dementia: a cohort study.Journal of epidemiology and community health · 2025Article
- Previous parity differentially influences cognition in later life depending on dementia status.NPJ dementia · 2025Article
- Research Note: The Association Between Parity and Odds of Alzheimer's Disease and Dementias Status.Demography · 2024Article
- Longitudinal associations of reproductive factors and exogeneous estrogens with neuroimaging biomarkers of Alzheimer's disease and cerebrovascular disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Adolescent stress accelerates postpartum novelty recognition impairment in 5xFAD mice.Frontiers in neuroscience · 2024Article
- Effects of reproductive experience on cost-benefit decision making in female rats.Frontiers in behavioral neuroscience · 2024Article
- Parity and Risk of Dementia in Women: The Atherosclerosis Risk in Communities Study.Journal of women's health (2002) · 2023Article
- Walking for Cognitive Health: Previous Parity Moderates the Relationship Between Self-Reported Walking and Cognition.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Retinal Venule Coverage by Pericytes Decreases in Multiparous Mice in a Time-Dependent Manner Post-Delivery.International journal of molecular sciences · 2023Article
- Article
- Associations Between Parity and Cognition: Race/Ethnic Differences.Journal of Alzheimer's disease : JAD · 2023Article
- The expectant brain-pregnancy leads to changes in brain morphology in the early postpartum period.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Associations of Parity With Change in Global Cognition and Incident Cognitive Impairment in Older Women.Frontiers in aging neuroscience · 2022Article
- Endogenous and Exogenous Estrogen Exposures: How Women's Reproductive Health Can Drive Brain Aging and Inform Alzheimer's Prevention.Frontiers in aging neuroscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiparity - grand multiparity (i.e., five or more childbirths) in particular - has been reported to have an association with increased risk of Alzheimer's disease (AD) dementia or related cognitive decline in women. However, the pathological links underlying this relationship are still unknown. This study was conducted to examine the relationships of multiparity with cerebral amyloid-beta (Aβ) deposition, brain atrophy, and white matter hyperintensities (WMHs).
methodsIn this study, total of 237 older women with 148 cognitively normal and 89 mild cognitive impairment from the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) were included. Participants underwent clinical and neuropsychological assessments in addition to
resultsParticipants with grand multiparity showed significantly reduced adjusted hippocampal volume, spatial pattern of atrophy for recognition of AD volume and spatial pattern of atrophy for recognition of brain aging volume even after controlling for potential confounders. Furthermore, MMSE score was also significantly lower in this group. In contrast, grand multiparity did not show any association with global Aβ retention, Aβ positivity rate, or WMH volume, regardless of covariates.
conclusionOur findings suggest that grand multiparity contributes to cognitive decline or increased dementia risk in older women by aggravating amyloid-independent hippocampal or cortical atrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.