Evidence map›Paper›PMID 32581765›Full record

ArticleFrontiers in aging neuroscience2020

Translation Imaging in Parkinson's Disease: Focus on Neuroinflammation.

Sara Belloli, Michele Morari, Valentina Murtaj, Silvia Valtorta, Rosa Maria Moresco, Maria Carla Gilardi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  19. TSPO imaging in animal models of brain diseases.European journal of nuclear medicine and molecular imaging · 2021
    Review
  20. Towards PET imaging of the dynamic phenotypes of microglia.Clinical and experimental immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Sara BelloliInstitute of Molecular Bioimaging and Physiology (IBFM), CNR, Milan, Italy.
Michele MorariSection of Pharmacology, Department of Medical Sciences, National Institute for Neuroscience, University of Ferrara, Ferrara, Italy.
Valentina MurtajNuclear Medicine Department, San Raffaele Scientific Institute (IRCCS), Milan, Italy.
Silvia ValtortaInstitute of Molecular Bioimaging and Physiology (IBFM), CNR, Milan, Italy.
Rosa Maria MorescoInstitute of Molecular Bioimaging and Physiology (IBFM), CNR, Milan, Italy.
Maria Carla GilardiInstitute of Molecular Bioimaging and Physiology (IBFM), CNR, Milan, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITInstitute of Molecular Bioimaging and Physiology · ITUniversity of Ferrara · ITUniversity of Milano-Bicocca · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the appearance of α-synuclein insoluble aggregates known as Lewy bodies. Neurodegeneration is accompanied by neuroinflammation mediated by cytokines and chemokines produced by the activated microglia. Several studies demonstrated that such an inflammatory process is an early event, and contributes to oxidative stress and mitochondrial dysfunctions. α-synuclein fibrillization and aggregation activate microglia and contribute to disease onset and progression. Mutations in different genes exacerbate the inflammatory phenotype in the monogenic compared to sporadic forms of PD. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) with selected radiopharmaceuticals allow

Indexed as

early disease markersmicroglianeuroinflammationoxidative stressParkinson’s diseasePD modelsPET radioligands

Identifiers

PMID32581765
PMCPMC7289967
OpenAlexW3033026625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.