Evidence map›Paper›PMID 32581753›Full record

ArticleFrontiers in human neuroscience2020

A Nexus Model of Restricted Interests in Autism Spectrum Disorder.

R McKell Carter, Heejung Jung, Judy Reaven, Audrey Blakeley-Smith, Gabriel S Dichter

Open access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Do focused interests support word learning? A study with autistic and nonautistic children.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  3. Profiles of circumscribed interests in autistic youth.Frontiers in behavioral neuroscience · 2023
    Article
  4. Autistic people outperform neurotypicals in a cartoon version of the Reading the Mind in the Eyes.Autism research : official journal of the International Society for Autism Research · 2022
    Article
  5. Toward better characterization of restricted and unusual interests in youth with autism.Autism : the international journal of research and practice · 2022
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

R McKell CarterInstitute of Cognitive Science, University of Colorado Boulder, Boulder, CO, United States.
Heejung JungInstitute of Cognitive Science, University of Colorado Boulder, Boulder, CO, United States.
Judy ReavenJFK Partners, Department of Psychiatry and Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Audrey Blakeley-SmithJFK Partners, Department of Psychiatry and Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Gabriel S DichterSchool of Medicine, Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
University of Colorado Anschutz Medical Campus · USUniversity of Colorado Boulder · USUniversity of North Carolina at Chapel Hill · US

Funding

A Simultaneous PET/MR Study of Striatal Dopamine Binding in AutismR21MH110933 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DICHTER, GABRIEL S, HOOKER, JACOB M. · 2016 to 2017
$448k
NIMH NIH HHS R21 MH110933
6 · The paper itself

Abstract

Restricted interests (RIs) in autism spectrum disorder (ASD) are clinically impairing interests of unusual focus or intensity. They are a subtype of restricted and repetitive behaviors which are one of two diagnostic criteria for the disorder. Despite the near ubiquity of RIs in ASD, the neural basis for their development is not well understood. However, recent cognitive neuroscience findings from nonclinical samples and from individuals with ASD shed light on neural mechanisms that may explain the emergence of RIs. We propose the nexus model of RIs in ASD, a novel conceptualization of this symptom domain that suggests that RIs may reflect a co-opting of brain systems that typically serve to integrate complex attention, memory, semantic, and social communication functions during development. The nexus model of RIs hypothesizes that when social communicative development is compromised, brain functions typically located within the lateral surface of cortex may expand into social processing brain systems and alter cortical representations of various cognitive functions during development. These changes, in turn, promote the development of RIs as an alternative process mediated by these brain networks. The nexus model of RIs makes testable predictions about reciprocal relations between the impaired development of social communication and the emergence of RIs in ASD and suggests novel avenues for treatment development.

Indexed as

autismcognitive neural developmentfMRIrestricted interestssocial perception

Identifiers

PMID32581753
PMCPMC7283772
OpenAlexW3032968570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.