ArticleFrontiers in human neuroscience2020
Neurophysiological Correlates of Gait in the Human Basal Ganglia and the PPN Region in Parkinson's Disease.
Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- "Brain-First" vs. "Body-First" PD: Definitions and Implications in Everyday Clinical Practice: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Modeling and optimizing deep brain stimulation to enhance gait in Parkinson's disease: personalized treatment with neurophysiological insights.NPJ Parkinson's disease · 2025Article
- Directional Subthalamic Deep Brain Stimulation Better Improves Gait and Balance Disorders in Parkinson's Disease Patients: A Randomized Controlled Study.Annals of neurology · 2024Article
- Vestibular Neurostimulation for Parkinson's Disease: A Novel Device-Aided Non-Invasive Therapeutic Option.Journal of personalized medicine · 2024Review
- Multiregional neural pathway: from movement planning to initiation.Signal transduction and targeted therapy · 2022Article
- Why Should Constant Stimulation of Saccular Afferents Modify the Posture and Gait of Patients with Bilateral Vestibular Dysfunction? The Saccular Substitution Hypothesis.Journal of clinical medicine · 2022Review
- Rhythmic auditory cueing in atypical parkinsonism: A pilot study.Frontiers in neurology · 2022Article
- Freezing of gait in Parkinson's disease is associated with the microstructural and functional changes of globus pallidus internus.Frontiers in aging neuroscience · 2022Article
- Freezing of Gait in Multiple System Atrophy.Frontiers in aging neuroscience · 2022Article
- Troubleshooting Gait Disturbances in Parkinson's Disease With Deep Brain Stimulation.Frontiers in human neuroscience · 2022Review
- Past, Present, and Future of Deep Brain Stimulation: Hardware, Software, Imaging, Physiology and Novel Approaches.Frontiers in neurology · 2022Review
- Gait-Phase Modulates Alpha and Beta Oscillations in the Pedunculopontine Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson's disease.Nature biotechnology · 2021Article
- Freezing of Gait in Parkinson's Disease: Invasive and Noninvasive Neuromodulation.Neuromodulation : journal of the International Neuromodulation Society · 2021Review
- Rhythm and Music-Based Interventions in Motor Rehabilitation: Current Evidence and Future Perspectives.Frontiers in human neuroscience · 2021Review
- Future Therapeutic Strategies for Freezing of Gait in Parkinson's Disease.Frontiers in human neuroscience · 2021Review
- MR Tractography-Based Targeting and Physiological Identification of the Cuneiform Nucleus for Directional DBS in a Parkinson's Disease Patient With Levodopa-Resistant Freezing of Gait.Frontiers in human neuroscience · 2021Article
- Closed-Loop Deep Brain Stimulation to Treat Medication-Refractory Freezing of Gait in Parkinson's Disease.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to characterize the neurophysiological correlates of gait in the human pedunculopontine nucleus (PPN) region and the globus pallidus internus (GPi) in Parkinson's disease (PD) cohort. Though much is known about the PPN region through animal studies, there are limited physiological recordings from ambulatory humans. The PPN has recently garnered interest as a potential deep brain stimulation (DBS) target for improving gait and freezing of gait (FoG) in PD. We used bidirectional neurostimulators to record from the human PPN region and GPi in a small cohort of severely affected PD subjects with FoG despite optimized dopaminergic medications. Five subjects, with confirmed on-dopaminergic medication FoG, were implanted with bilateral GPi and bilateral PPN region DBS electrodes. Electrophysiological recordings were obtained during various gait tasks for 5 months postoperatively in both the off- and on-medication conditions (obtained during the no stimulation condition). The results revealed suppression of low beta power in the GPi and a 1-8 Hz modulation in the PPN region which correlated with human gait. The PPN feature correlated with walking speed. GPi beta desynchronization and PPN low-frequency synchronization were observed as subjects progressed from rest to ambulatory tasks. Our findings add to our understanding of the neurophysiology underpinning gait and will likely contribute to the development of novel therapies for abnormal gait in PD.
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