ArticleFrontiers in human neuroscience2020
Alterations of Interhemispheric Functional Connectivity in Parkinson's Disease With Depression: A Resting-State Functional MRI Study.
Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Altered habenular and whole brain functional connectivity in early Parkinson's disease using 7 T MRI.NPJ Parkinson's disease · 2025Article
- Multimodal magnetic resonance imaging studies on non-motor symptoms of Parkinson's disease.IBRO neuroscience reports · 2025Article
- Exploring brain asymmetry in early-stage Parkinson's disease through functional and structural MRI.CNS neuroscience & therapeutics · 2024Article
- Altered functional-structural coupling may predict Parkinson's patient's depression.Brain structure & function · 2024Article
- Distinct changes in global brain synchronization in different motor subtypes of Parkinson's disease.Frontiers in neuroscience · 2023Article
- The pathobiological basis of depression in Parkinson disease: challenges and outlooks.Journal of neural transmission (Vienna, Austria : 1996) · 2022Review
- Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- Aberrant functional connectivity and activity in Parkinson's disease and comorbidity with depression based on radiomic analysis.Brain and behavior · 2021Article
- Multisite non-invasive brain stimulation in Parkinson's disease: A scoping review.NeuroRehabilitation · 2021Article
- Distinct Changes in Global Brain Synchronization in Early-Onset vs. Late-Onset Parkinson Disease.Frontiers in aging neuroscience · 2020Article
- Networks Are Associated With Depression in Patients With Parkinson's Disease: A Resting-State Imaging Study.Frontiers in neuroscience · 2020Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression is the most common non-motor symptom in patients with Parkinson's disease (PD) with unknown mechanisms, but the diagnostic criteria of PD with depression (PDD) are not uniform. PURPOSE: The aim of the study was to investigate interhemispheric interactions between PDD patients and patients with PD without depression (PDND).
methodsThe voxel-mirrored homotopic connectivity (VMHC) combined with the seed-based method was used to investigate intrinsic resting-state functional connectivity (RSFC) in 33 PDD patients, 60 PDND, and 47 healthy controls (HCs).
resultsPDD patients exhibited a decreased VMHC in the bilateral medial frontal gyrus and paracentral lobule (MFG/PCL) than did PDND patients. Parkinson's disease with depression had a decreased VMHC in the bilateral precentral gyrus than had PDND and HC (
conclusionsOur findings indicated that the occurrence of depression in Parkinson's disease is associated with the dysfunctional connectivity from the MFG/PCL to the contralateral SMA, which could be used as potential neuroimaging markers for the diagnosis of depression in PD patients.
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