ArticleFrontiers in systems neuroscience2020
Long-Term Neuroanatomical Consequences of Childhood Maltreatment: Reduced Amygdala Inhibition by Medial Prefrontal Cortex.
Article in Frontiers in systems neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- A Meta-Analysis of the Effects of Early Life Stress on the Prefrontal Cortex Transcriptome Reveals Long-Term Downregulation of Myelin-Related Gene Expression.Brain and behavior · 2025Pooled it
- Sad emotion processing-related theta oscillation patterns link suicide attempt to childhood trauma in depression: evidence from MEG.Translational psychiatry · 2026Article
- [The Bidirectional relationship between chronic pain and traumatic life events : Mechanisms and therapeutic implications].Schmerz (Berlin, Germany) · 2025Review
- Network Specificity in Predicting Childhood Trauma Characteristics Using Effective Connectivity.Alpha psychiatry · 2025Article
- Development and Validation of an Online Intervention Program to Augment Psychological Resilience: A Randomized Waitlist-Controlled Trial.Psychiatry investigation · 2025Article
- Prophylactic (R,S)-Ketamine and (2S,6S)-Hydroxynorketamine Decrease Fear Expression by Differentially Modulating Fear Neural Ensembles.Biological psychiatry · 2025Article
- Behavioral moderators ofFrontiers in psychiatry · 2025Article
- Gender differences in the associations of recreational walking with indoor and outdoor falls among older adults-the Healthy Aging and Neighborhood Study (HANS).AIMS public health · 2025Article
- Neuromodulation of Fear and Anxiety Circuits.Current topics in behavioral neurosciences · 2025Review
- Altered Brain Functional Connectivity and Peripheral Transcriptomic Profiles in Major Depressive Disorder With Childhood Maltreatment.Depression and anxiety · 2025Article
- Common neural correlates of disgust processing in childhood maltreatment and peer victimisation.BJPsych open · 2024Article
- Divergent Effects of Ketamine and the Serotoninergic Psychedelic 2,5-Dimethoxy-4-Iodoamphetamine on Hippocampal Plasticity and Metaplasticity.Psychedelic medicine (New Rochelle, N.Y.) · 2024Article
- Childhood Maltreatment and Amygdala-Mediated Anxiety and Posttraumatic Stress Following Adult Trauma.Biological psychiatry global open science · 2024Article
- The Dichotomy of Threat and Deprivation as Subtypes of Childhood Maltreatment: Differential Functional Connectivity Patterns of Threat and Reward Circuits in an Adult Trauma Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Autistic and non-autistic individuals show the same amygdala activity during emotional face processing.Molecular autism · 2024Article
- Human emotion processing accuracy, negative biases, and fMRI activation are associated with childhood trauma.Frontiers in psychiatry · 2023Article
- Childhood maltreatment and its role in the development of pain and psychopathology.The Lancet. Child & adolescent health · 2022Review
- Revisiting the effective connectivity within the distributed cortical network for face perception.Neuroimage. Reports · 2021Article
- The German research consortium for the study of bipolar disorder (BipoLife): a magnetic resonance imaging study protocol.International journal of bipolar disorders · 2021Article
- Childhood maltreatment results in altered deactivation of reward processing circuits in depressed patients: A functional magnetic resonance imaging study of a facial emotion recognition task.Neurobiology of stress · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Similar to patients with Major depressive disorder (MDD), healthy subjects at risk for depression show hyperactivation of the amygdala as a response to negative emotional expressions. The medial prefrontal cortex is responsible for amygdala control. Analyzing a large cohort of healthy subjects, we aimed to delineate malfunction in amygdala regulation by the medial prefrontal cortex in subjects at increased risk for depression, i.e., with a family history of affective disorders or a personal history of childhood maltreatment. We included a total of 342 healthy subjects from the
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.