ArticleFrontiers in cellular neuroscience2020
The Basal Forebrain Modulates Neuronal Response in an Active Olfactory Discrimination Task.
Article in Frontiers in cellular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Glutamatergic projection neurons in the basal forebrain underlie learned olfactory associational valence assignments.Nature communications · 2026Article
- Respiration-coordinated attentional switch from feedforward to top-down informational flow directed by the basal forebrain: layer-specific blanket inhibition of pyramidal cells by neurogliaform cells in the piriform cortex.Frontiers in neural circuits · 2026Review
- Basal forebrain cholinergic input mediates adaptive attention allocation to enhance olfactory discrimination.PLoS biology · 2025Article
- Dopaminergic short axon cells integrate sensory and top-down inputs to enhance discriminative learning in the mouse olfactory bulb.PLoS biology · 2025Article
- Subcortical nuclei of the human ascending arousal system encode anticipated reward but do not predict subsequent memory.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Distinct Patterns of PV and SST GABAergic Neuronal Activity in the Basal Forebrain during Olfactory-Guided Behavior in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Calretinin-Expressing Neurons in the Basal Forebrain Specifically Contact Granule Cells in the Olfactory Bulb and Modulate Odor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior.Scientific reports · 2022Article
- Basal Forebrain-Dorsal Hippocampus Cholinergic Circuit Regulates Olfactory Associative Learning.International journal of molecular sciences · 2022Article
- Olfactory function and discrimination ability in the elderly: a pilot study.The journal of physiological sciences : JPS · 2022Article
- The Response Dynamics and Function of Cholinergic and GABAergic Neurons in the Basal Forebrain During Olfactory Learning.Frontiers in cellular neuroscience · 2022Article
- The Regulation Effect ofMediators of inflammation · 2021Review
- Dynamic Cholinergic Tone in the Basal Forebrain Reflects Reward-Seeking and Reinforcement During Olfactory Behavior.Frontiers in cellular neuroscience · 2021Article
- Basal Forebrain Modulation of Olfactory CodingInternational journal of psychological researchArticle
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Successful completion of sensory decision-making requires focusing on relevant stimuli, adequate signal/noise ratio for stimulus discrimination, and stimulus valence evaluation. Different brain regions are postulated to play a role in these computations; however, evidence suggests that sensory and decision-making circuits are required to interact through a common neuronal pathway to elicit a context-adequate behavioral response. Recently, the basal forebrain (BF) region has emerged as a good candidate, since its heterogeneous projecting neurons innervate most of the cortical mantle and sensory processing circuits modulating different aspects of the sensory decision-making process. Moreover, evidence indicates that the BF plays an important role in attention and in fast modulation of neuronal activity that enhance visual and olfactory sensory perception. Here, we study in awake mice the involvement of BF in initiation and completion of trials in a reward-driven olfactory detection task. Using tetrode recordings, we find that BF neurons (including cholinergics) are recruited during sensory discrimination, reward, and interestingly slightly before trial initiation in successful discrimination trials. The precue neuronal activity was correlated with animal performance, indicating that this circuit could play an important role in adaptive context-dependent behavioral responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.