ArticleFrontiers in neuroscience2020
Monitoring of Stimulus Evoked Murine Somatosensory Cortex Hemodynamic Activity With Volumetric Multi-Spectral Optoacoustic Tomography.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography.Light, science & applications · 2025Article
- In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons.Nature communications · 2024Article
- Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells.Nature communications · 2024Article
- Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain.Photoacoustics · 2023Article
- Simultaneous Functional Magnetic Resonance and Optoacoustic Imaging of Brain-Wide Sensory Responses in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Monitoring neonatal brain hemorrhage progression by photoacoustic tomography.Biomedical optics express · 2023Article
- Deep learning facilitates fully automated brain image registration of optoacoustic tomography and magnetic resonance imaging.Biomedical optics express · 2022Article
- Multimodal Noninvasive Functional Neurophotonic Imaging of Murine Brain-Wide Sensory Responses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Multi-scale optoacoustic molecular imaging of brain diseases.European journal of nuclear medicine and molecular imaging · 2021Review
- 3D Monte Carlo simulation of light distribution in mouse brain in quantitative photoacoustic computed tomography.Quantitative imaging in medicine and surgery · 2021Article
- Photoacoustic Neuroimaging - Perspectives on a Maturing Imaging Technique and its Applications in Neuroscience.Frontiers in neuroscience · 2021Review
- Article
- A Systematic Review of Cerebral Functional Near-Infrared Spectroscopy in Chronic Neurological Diseases-Actual Applications and Future Perspectives.Diagnostics (Basel, Switzerland) · 2020Review
- Brain-wide hemodynamic responses to precise transcranial ultrasound neuromodulation.Brain stimulationArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensory stimulation is an attractive paradigm for studying brain activity using various optical-, ultrasound- and MRI-based functional neuroimaging methods. Optoacoustics has been recently suggested as a powerful new tool for scalable mapping of multiple hemodynamic parameters with rich contrast and previously unachievable spatio-temporal resolution. Yet, its utility for studying the processing of peripheral inputs at the whole brain level has so far not been quantified. We employed volumetric multi-spectral optoacoustic tomography (vMSOT) to non-invasively monitor the HbO, HbR, and HbT dynamics across the mouse somatosensory cortex evoked by electrical paw stimuli. We show that elevated contralateral activation is preserved in the HbO map (invisible to MRI) under isoflurane anesthesia. Brain activation is shown to be predominantly confined to the somatosensory cortex, with strongest activation in the hindpaw region of the contralateral sensorimotor cortex. Furthermore, vMSOT detected the presence of an initial dip in the contralateral hindpaw region in the delta HbO channel. Sensorimotor cortical activity was identified over all other regions in HbT and HbO but not in HbR. Pearson's correlation mapping enabled localizing the response to the sensorimotor cortex further highlighting the ability of vMSOT to bridge over imaging performance deficiencies of other functional neuroimaging modalities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.