ReviewLocal and regional anesthesia2020
Control of Spinal Anesthesia-Induced Hypotension in Adults.
Review in Local and regional anesthesia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Two Different Doses of Intramuscular Phenylephrine HCL for Prevention of Spinal Anesthesia Induced Hypotension During Cesarean Section: A Prospective Randomized Double-blinded Parallel Study
Do Compression Stockings Used During Cesarean Sections Affect Intraoperative Hypotension and Nausea?
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Comparing the Effect of Spinal and General Anesthesia for Hip Fracture Surgery in Older Patients: A Meta-analysis of Randomized Clinical Trials.Orthopaedic surgery · 2023Pooled it
- Impact of bupivacaine dose on haemodynamics in elderly hip surgery: a randomized controlled trial.BMC geriatrics · 2026Trial
- Leg compression for preventing hypotension after spinal anesthesia in elderly hip fracture patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Trial
- Efficacy of Low-Dose Intravenous Ketamine With Spinal Anesthesia for Postoperative Pain Control in Total Knee Arthroplasty: A Randomized Clinical Trial.Pain research & management · 2026Trial
- The Effectiveness and Safety of Dural Puncture Epidural for Aged Patients Undergoing Orthopedic Surgery: A Randomized Controlled Trial.Clinical interventions in aging · 2026Trial
- Effect of esketamine on hypotension in women with preoperative anxiety undergoing elective cesarean section: a randomized, double-blind, controlled trial.Scientific reports · 2024Trial
- The Median Effective Dose of Intrathecal Hyperbaric Bupivacaine for Cesarean Section at Moderately High-Altitude.Drug design, development and therapy · 2024Trial
- Determination of ED90s of Phenylephrine and Norepinephrine Infusion for Prevention of Spinal Anesthesia-Induced Hypotension in Patients with Preeclampsia During Cesarean Delivery.Drug design, development and therapy · 2024Trial
- Norepinephrine prevents hypotension in older patients under spinal anesthesia with intravenous propofol sedation: a randomized controlled trial.Scientific reports · 2023Trial
- Impact of forced diuresis on retropulsion of disintegrated ureteral calculi during semi-rigid ureteroscopy: a double-blind randomized-controlled study.Urolithiasis · 2022Trial
- Association Between Immediate Postoperative Pulse Pressure and Three-Year All-Cause Mortality After Hip Fracture Surgery in Older Adults: A Post Hoc Analysis of a Prospective Cohort.Journal of clinical medicine · 2026Article
- Effect of granisetron on the spinal anesthesia-induced hemodynamic changes: a meta-analysis of randomized controlled trials.Journal of anesthesia · 2026Article
- Article
- Clinical Outcomes of Lumboperitoneal Shunt Surgery for Normal Pressure Hydrocephalus : A 5-Year Single-Center Retrospective Study of Patients with at Least 1 Year of Follow-Up.Journal of Korean Neurosurgical Society · 2026Article
- A Nomogram for Predicting the Risk of Spinal Anesthesia-Induced Hypotension in Older Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Position-Induced Change in Carotid Corrected Flow Time Predicts Spinal Hypotension in Cesarean Delivery.International journal of women's health · 2026Article
- Perioperative Sympathetic Blockade: Mechanisms and Clinical Advances in Sensory Processing Modulation - A Narrative Review.Journal of pain research · 2026Review
- Prevention of post-spinal hypotension in high risk cesarean delivery: A systematic review and updated network meta-analysis of prophylactic vasopressor infusions.Indian journal of anaesthesia · 2026Article
- Hyponatraemia After Hip and Knee Replacement: Incidence, Risk Factors, Clinical Consequences and Management in the Era of Enhanced Recovery.Clinics and practice · 2025Review
- The incidence and associated factors of hypotension during spinal anesthesia at tertiary hospital: a prospective cross-sectional study.Annals of medicine and surgery (2012) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal anesthesia-induced hypotension (SAIH) occurs frequently, particularly in the elderly and in patients undergoing caesarean section. SAIH is caused by arterial and venous vasodilatation resulting from the sympathetic block along with a paradoxical activation of cardioinhibitory receptors. Bradycardia after spinal anesthesia (SA) must always be treated as a warning sign of an important hemodynamic compromise. Fluid preloading (before initiation of the SA) with colloids such as hydroxyethyl starch (HES) effectively reduces the incidence and severity of arterial hypotension, whereas crystalloid preloading is not indicated. Co-loading with crystalloid or colloid is as equally effective to HES preloading, provided that the speed of administration is adequate (ie, bolus over 5 to 10 minutes). Ephedrine has traditionally been considered the vasoconstrictor of choice, especially for use during SAIH associated with bradycardia. Phenylephrine, a α
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.