Evidence map›Paper›PMID 32581537›Full record

ArticleInternational journal of nanomedicine2020

The Antibiofilm Activity and Mechanism of Nanosilver- and Nanozinc-Incorporated Mesoporous Calcium-Silicate Nanoparticles.

Diya Leng, Yan Li, Jie Zhu, Ruizhen Liang, Cuifeng Zhang, Yang Zhou, Mingming Li, Ying Wang, Di Rong, Daming Wu and 1 more

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  11. Antibacterial and Antibiofilm Activity ofMolecules (Basel, Switzerland) · 2023
    Article
  12. Review
  13. Article
  14. Review
  15. Mesoporous Bioactive Nanoparticles for Bone Tissue Applications.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Review
  18. Article
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  20. Activity of Silver Nanoparticles againstInternational journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Diya Leng *Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, People's Republic of China.
Yan Li *State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, People's Republic of China.ORCID 0000-0002-0184-8439
Jie ZhuDepartment of Stomatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Ruizhen LiangJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, People's Republic of China.
Cuifeng ZhangJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, People's Republic of China.
Yang ZhouJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, People's Republic of China.
Mingming LiJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, People's Republic of China.
Ying WangJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, People's Republic of China.
Di RongJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, People's Republic of China.
Daming WuJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, People's Republic of China.
Jin LiJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, People's Republic of China.ORCID 0000-0002-5891-8135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMesoporous calcium-silicate nanoparticles (MCSNs) have good prospects in the medical field due to their great physicochemical characteristics, antibacterial activity and drug delivery capacity. This study was to analyze the antibiofilm activity and mechanisms of silver (Ag) and zinc (Zn) incorporated MCSNs (Ag/Zn-MCSNs) with different percentages of Ag and Zn.

methodsAg/Zn(1:9, molar ratio)-MCSNs and Ag/Zn(9:1, molar ratio)-MCSNs were prepared and characterized. Endocytosis of nanoparticles by

resultsThe Ag/Zn-MCSNs release Ag

conclusionAg/Zn-MCSNs have good antibiofilm activity. They might achieve an appropriate balance between the antibacterial activity and cytotoxicity by adjusting the ratio of Ag and Zn. Ag/Zn-MCSNs are expected to be a new type of root canal disinfectant or sealer for root canal treatment.

Indexed as

AnimalsAnti-Bacterial AgentsBiofilmsCalcium CompoundsDental Pulp CavityDentinEndocytosisEnterococcus faecalisGram-Positive Bacterial InfectionsHumansMiceNanoparticlesOsteoblastsPorositySilicatesSilverAnti-Bacterial AgentsCalcium Compoundscalcium silicateSilicatesSilverZincantibacterial mechanismantibiofilmmesoporous calcium-silicate nanoparticlessilverzinc

Identifiers

PMID32581537
PMCPMC7278446

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.