Phenotype variability and different genotype of four patients with thyroid hormone resistance syndrome due to variants in the THRB gene.

M Toumba, V Neocleous, P Fanis, G A Tanteles, M Kyriakidou-Himonas, M Picolos

Open access · greenAbstract readCase Reports

In one paragraph

Article in Hippokratia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.5field-weighted citation impact, top 30% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

Lingual thyroid and resistance to thyroid hormone beta due to a novel THRB c.1312 C > T mutation in a child: diagnostic pitfalls and management.Endocrine · 2026
Article
TSH adenoma and syndrome of resistance to thyroid hormones-Two cases report of syndrome of inappropriate secretion of thyrotropin.Brain and behavior · 2021
Article
Resistance to Thyroid Hormone Beta: A Focused Review.Frontiers in endocrinology · 2021
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M ToumbaPediatric Endocrine Clinic, IASIS Hospital, Paphos, Cyprus.

V NeocleousDepartment of Molecular Genetics, Function & Therapy, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus.

P FanisDepartment of Molecular Genetics, Function & Therapy, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus.

G A TantelesCyprus School of Molecular Medicine, Nicosia, Cyprus.

M Kyriakidou-HimonasLarnaca Endocrinology Center, Larnaca, Cyprus.

M PicolosAlithias Endocrinology Center, Nicosia, Cyprus.

Cyprus Institute of Neurology and Genetics · CY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResistance to thyroid hormone (RTH) is a rare dominantly inherited disorder mainly due to variants in the CASE REPORT: Clinical and molecular characteristics of four patients with RTH are described. Four patients with various phenotypes were studied; two prepubertal boys and two adults (one male and one female). Sequencing analysis of the

conclusionsVarious phenotypes characterize common variants in the

Indexed as

free thyroxinefree triiodothyronineFT3FT4resistance to thyroid hormoneTHRB geneThyroidthyroid stimulating hormoneTSH

Identifiers

PMID32581500

PMCPMC7307508

OpenAlexW3037702169

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.