Evidence map›Paper›PMID 32581380›Full record

ArticleNature2020

Reversing a model of Parkinson's disease with in situ converted nigral neurons.

Hao Qian, Xinjiang Kang, Jing Hu, Dongyang Zhang, Zhengyu Liang, Fan Meng, Xuan Zhang, Yuanchao Xue, Roy Maimon, Steven F Dowdy and 5 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 274 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
274citing papers in PubMed, 1 pooled it
33.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

274 citing papers in PubMed, 1 synthesis or guideline pooled it, 481 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

214 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Hao QianDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Xinjiang KangState Key Laboratory of Membrane Biology and Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, China.
Jing HuDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Dongyang ZhangDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-2365-4763
Zhengyu LiangDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Fan MengDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Xuan ZhangDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Yuanchao XueDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8113-2333
Roy MaimonDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Steven F DowdyDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Neal K DevarajDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8033-9973
Zhuan ZhouState Key Laboratory of Membrane Biology and Peking-Tsinghua Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, China.ORCID http://orcid.org/0000-0001-9048-6638
William C MobleyDepartment of Neurosciences and Center for Neural Circuits and Behavior, University of California, San Diego, La Jolla, CA, USA.
Don W ClevelandDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1934-3682
Xiang-Dong FuDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA. xdfu@ucsd.edu.ORCID http://orcid.org/0000-0001-5499-8732
University of California San Diego · USPeking University · CNChinese Academy of Sciences · CNUniversity of Electronic Science and Technology of China · CN

Funding

FUNCTION &REGULATION OF THE HUMAN SPLICING FACTOR SC35R01GM049369 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FU, XIANG-DONG · 1993 to 2018
$7.2M
Regulation of RNA metabolism and cell growth control by SR protein kinasesR01GM052872 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOWDY, STEVEN F · 1996 to 2019
$5.4M
NIGMS NIH HHS R01 GM049369NIGMS NIH HHS R01 GM052872NIH HHS GM049369NIH HHS GM052872
6 · The paper itself

Abstract

Parkinson's disease is characterized by loss of dopamine neurons in the substantia nigra

Indexed as

Disease Models, AnimalAnimalsAstrocytesAxonsDopamineDopaminergic NeuronsFemaleHeterogeneous-Nuclear RibonucleoproteinsHumansIn Vitro TechniquesMaleMiceNeostriatumNeural PathwaysNeurogenesisParkinson DiseaseDopamineHeterogeneous-Nuclear RibonucleoproteinsPolypyrimidine Tract-Binding ProteinPTBP1 protein, humanPtbp1 protein, mouse

Identifiers

PMID32581380
PMCPMC7521455
OpenAlexW3037521146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.