ArticleNature2020
Structure of human GABA
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 95 citations in OpenAlex.
- International Union of Basic and Clinical Pharmacology. CXXII. Applying an objective evaluation to the status of class A orphan G protein-coupled receptors.Pharmacological reviews · 2026Review
- Normalization of network activity in an epilepsy model with a constitutively active GABBR2 variant.Brain : a journal of neurology · 2026Article
- Conformational equilibria in the activation of cystine-knot hormone receptors.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Functional and structural basis of a negative allostery within GABANature communications · 2026Article
- GPCR Heterodimers: Implications for Biased Signaling.Handbook of experimental pharmacology · 2026Review
- Structure of an LGR dimer, an evolutionary predecessor of glycoprotein hormone receptors.Nature communications · 2025Article
- GABA-independent activation of GABANature communications · 2025Article
- G Protein-Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers.MedComm · 2025Review
- Structural Basis of GABAAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Molecular contacts in self-assembling clusters of membrane proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A large-scale curated and filterable dataset for cryo-EM foundation model pre-training.Scientific data · 2025Article
- Identification of Orthosteric GABAACS omega · 2025Article
- GABAMedComm · 2025Review
- Direct effect of membrane environment on the activation of mGluR2 revealed by single-molecule FRET.Structure (London, England : 1993) · 2025Article
- A tale of detergent tails: GPCR activation beyond ligands.Structure (London, England : 1993) · 2025Article
- Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant.Brain : a journal of neurology · 2025Article
- The function of GPCRs in different bone cells.International journal of biological sciences · 2025Review
- Molecular insights into the activation mechanism of GPR156 in maintaining auditory function.Nature communications · 2024Article
- Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer.Nature communications · 2024Article
- Cryo-EM structure of human class C orphan GPCR GPR179 involved in visual processing.Nature communications · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
34 authors at 9 institutions in 3 countries.
Jinseo Park *Department of Pharmacology, Columbia University, New York, NY, USA.
Ziao Fu *Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-5036-1945
Aurel Frangaj *Department of Pharmacology, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-4990-513X
Jonathan Liu *Department of Pharmacology, Columbia University, New York, NY, USA.
Lidia Mosyak *Department of Pharmacology, Columbia University, New York, NY, USA.
Tong Shen *NIH West Coast Metabolomics Center, University of California Davis, Davis, CA, USA.
Vesna N SlavkovichDepartment of Environmental Health Sciences, Columbia University, New York, NY, USA.
Kimberly M RayDepartment of Pharmacology, Columbia University, New York, NY, USA.
Jaume TauraNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Baohua CaoDepartment of Pharmacology, Columbia University, New York, NY, USA.
Yong GengDepartment of Pharmacology, Columbia University, New York, NY, USA.
Hao ZuoDepartment of Pharmacology, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-8812-7385
Yongjun KouKey Laboratory of Receptor Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Robert GrassucciDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Shaoxia ChenMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-9472-4397
Zheng LiuDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Xin LinDepartment of Psychiatry, Columbia University, New York, NY, USA.
Justin P WilliamsDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0003-4108-5808
William J RiceNational Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.
Edward T EngNational Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8014-7269
Rick K HuangJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Rajesh K SoniProteomics Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.
Brian KlossCenter on Membrane Protein Production and Analysis, New York Structural Biology Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0130-8739
Zhiheng YuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Jonathan A JavitchDepartment of Pharmacology, Columbia University, New York, NY, USA.
Wayne A HendricksonDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.
Paul A SlesingerNash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-3868-7528
Matthias QuickDepartment of Psychiatry, Columbia University, New York, NY, USA.
Joseph GrazianoDepartment of Environmental Health Sciences, Columbia University, New York, NY, USA.
Hongtao YuHoward Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-8861-049X
Oliver FiehnNIH West Coast Metabolomics Center, University of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-6261-8928
Oliver B ClarkeDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA. oc2188@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-1876-196X
Joachim FrankDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA. jf2192@cumc.columbia.edu.ORCID http://orcid.org/0000-0001-5449-6943
Qing R FanDepartment of Pharmacology, Columbia University, New York, NY, USA. qf13@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-9330-0963
Columbia University · USNew York Structural Biology Center · USColumbia University Irving Medical Center · USHoward Hughes Medical Institute · USNew York Psychoanalytic Society and Institute · USAllen Institute for Brain Science · USChinese Academy of Sciences · CNUniversity of California, Davis · USMRC Laboratory of Molecular Biology · GB
Funding
True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7MZWITTERION SURFACTANT DDMAB FOR IMPROV STABIL OF PROTEINP41RR001209 · NCRR · STANFORD UNIVERSITY · PI GONZALEZ, ANA M · 1985 to 2011
$38.9MY-FAMILY POLYMERASES AND CO-FACTORS IN TRANSLESION REPLICATIONP41RR015301 · NCRR · CORNELL UNIVERSITY ITHACA · PI EISENBERG, DAVID · 2001 to 2011
$28.2MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MTraining (303-338)P41GM116799 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2016 to 2020
$7.1MStructural Analysis of Alcohol-dependent Activation of GIRKsR01AA018734 · NIAAA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Paul A Slesinger · 2010 to 2026
$6.6MWest Coast Metabolomics Center for Compound IdentificationU2CES030158 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2018 to 2021
$4.1MProposal for an Administrative Supplement for Equipment Purchases for NIGMS Awardees NOT-GM-18-022R01GM107462 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HENDRICKSON, WAYNE A. · 2014 to 2021
$3.6MMolecular mechanism of dimeric G protein-coupled receptor signalingR35GM141871 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QING R FAN · 2021 to 2026
$2.7MMechanism of activation and modulation in human GABA(B) receptorR01GM125801 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FAN, QING R, QUICK, MATTHIAS · 2018 to 2021
$1.7MStructural Studies of Metabotropic GABA ReceptorsR01GM088454 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FAN, QING R · 2009 to 2015
$1.6MANOMALOUS-SCATTERING STUDIES OF MACROMOLECULAR STRUCTURER37GM034102 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENDRICKSON, WAYNE A. · 1994 to 2003
$1.4MMedical Research Council MC_U105184326NCRR NIH HHS P41 RR001209NCRR NIH HHS P41 RR015301NIAAA NIH HHS R01 AA018734NIEHS NIH HHS P30 ES009089NIEHS NIH HHS U2C ES030158NIGMS NIH HHS P41 GM103310NIGMS NIH HHS P41 GM116799NIGMS NIH HHS R01 GM088454NIGMS NIH HHS R01 GM107462NIGMS NIH HHS R01 GM112973NIGMS NIH HHS R01 GM125801NIGMS NIH HHS R35 GM141871NIGMS NIH HHS R37 GM034102NINDS NIH HHS R21 NS113614
Abstract
The human GABA
Indexed as
Cryoelectron MicroscopyCalciumEthanolaminesHumansLigandsModels, MolecularPhosphorylcholineProtein DomainsProtein MultimerizationProtein SubunitsReceptors, GABA-BStructure-Activity RelationshipCalciumEthanolaminesLigandsPhosphorylcholinephosphorylethanolamineProtein SubunitsReceptors, GABA-B
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.