ArticleNature2020
Pervasive lesion segregation shapes cancer genome evolution.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06717295 (The CCANED-CIPHER Study), which is not on this map. Cited by 51 papers.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The CCANED-CIPHER Study: Early Cancer Detection and Treatment Response Monitoring Using AI-Based Platelet and Immune Cell Transcriptomic Profiling
Who cites it
51 citing papers in PubMed, 69 citations in OpenAlex.
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Corrections and comments
- Commented on by
- Commented on by
Authors and funding
30 authors at 9 institutions in 3 countries.
Sarah J AitkenCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-1897-4140
Craig J Anderson *MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Frances Connor *Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2858-9411
Oriol PichInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0002-1956-1882
Vasavi SundaramCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Christine FeigCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Tim F RaynerCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Margus LukkCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Stuart AitkenMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4867-4568
Juliet LuftMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Elissavet KentepozidouEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Claudia Arnedo-PacInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2037-8487
Sjoerd V BeentjesSchool of Mathematics and Maxwell Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-7998-4262
Susan E DaviesDepartment of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Ruben M DrewsCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Ailith EwingMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Vera B KaiserMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Ava KhamsehMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5203-2205
Erika López-ArribillagaInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Aisling M RedmondCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Javier Santoyo-LopezEdinburgh Genomics (Clinical), The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1988-5059
Inés SentísInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Lana TalmaneMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Andrew D YatesEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Liver Cancer Evolution Consortium
Colin A SempleMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1765-4118
Núria López-BigasInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
Paul FlicekCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3897-7955
Duncan T OdomCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK. Duncan.Odom@cruk.cam.ac.uk.ORCID http://orcid.org/0000-0001-6201-5599
Martin S TaylorMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. martin.taylor@igmm.ed.ac.uk.ORCID http://orcid.org/0000-0001-7656-330X
Institute of Genetics and Cancer · GBUniversity of Cambridge · GBInstitute for Research in Biomedicine · ESEuropean Bioinformatics Institute · GBGerman Cancer Research Center · DEInstitució Catalana de Recerca i Estudis Avançats · ESCambridge University Hospitals NHS Foundation Trust · GBEdinburgh Genomics · GBMaxwell Institute for Mathematical Sciences · GB
Funding
Cancer Research UK 20412Cancer Research UK 22398Cancer Research UK A20412Cancer Research UK A22398European Research Council 615584Medical Research Council MC_UU_00007/11Medical Research Council MC_UU_00007/16Medical Research Council MC_UU_00009/2Medical Research Council MR/R026017/1Wellcome Trust 106563Wellcome Trust 202878Wellcome Trust 202878/Z/16/ZWellcome Trust WT106563/Z/14/AWellcome Trust WT108749/Z/15/ZWellcome Trust WT202878/B/16/Z
Abstract
Cancers arise through the acquisition of oncogenic mutations and grow by clonal expansion
Indexed as
Evolution, MolecularAllelesAnimalsChromosome SegregationDNA RepairDNA ReplicationErbB ReceptorsGenomeHumansLiver NeoplasmsMaleMiceMutationNeoplasmsraf Kinasesras ProteinsEGFR protein, mouseErbB Receptorsraf Kinasesras Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT06717295ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.