SynthesisNature2020
FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 15 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 15 pooled it
10.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 15 syntheses or guidelines pooled it, 147 citations in OpenAlex.
- Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto's thyroiditis.Nature genetics · 2026Pooled it
- Investigating the shared genetic architecture between selective immunoglobulin A deficiency and autoimmune diseases.Human genetics · 2026Pooled it
- Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.Nature genetics · 2026Pooled it
- Genome-wide association study and polygenic risk prediction of hypothyroidism.Nature genetics · 2025Pooled it
- Genetic correlation and causal relationships between autoimmune thyroid disease and major depressive disorders.Acta neuropsychiatrica · 2025Pooled it
- Pooled it
- Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency.Clinical immunology (Orlando, Fla.) · 2024Pooled it
- Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.Nature communications · 2024Pooled it
- Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study.Thyroid : official journal of the American Thyroid Association · 2023Pooled it
- Association of distance to swine concentrated animal feeding operations with immune-mediated diseases: An exploratory gene-environment study.Environment international · 2023Pooled it
- Shared genetic risk factors and causal association between psoriasis and coronary artery disease.Nature communications · 2022Pooled it
- Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis.Nature genetics · 2022Pooled it
- A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome.Nature communications · 2022Pooled it
- A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo.Communications biology · 2021Pooled it
- Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor.Communications biology · 2021Pooled it
- Shared genetic architecture and pathways linking major depressive disorder and autoimmune thyroid disease: insights from common and rare variants.Translational psychiatry · 2026Article
- Bidirectional association between immune-mediated diseases and major depressive disorder: evidence from cohort, genome-wide pleiotropic, and experimental studies.Molecular psychiatry · 2026Article
- Article
- Design and interpretation of eQTL-GWAS colocalisation studies: Lessons from a large-scale evaluation.PLoS genetics · 2026Article
- Interferon signaling gene expression, and DNA methylation interactions in Sjögren's disease via mendelian randomization.iScience · 2026Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 4 institutions in 2 countries.
Saedis SaevarsdottirdeCODE genetics/Amgen, Reykjavik, Iceland. saedis.saevarsdottir@decode.is.ORCID http://orcid.org/0000-0001-9392-6184
Thorunn A OlafsdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Erna V IvarsdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Gisli H HalldorssondeCODE genetics/Amgen, Reykjavik, Iceland.
Kristbjorg GunnarsdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Asgeir SigurdssondeCODE genetics/Amgen, Reykjavik, Iceland.
Ari JohannessonDepartment of Medicine, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland.
Jon K SigurdssondeCODE genetics/Amgen, Reykjavik, Iceland.
Thorhildur JuliusdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Sigrun H LunddeCODE genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-3806-2296
Asgeir O ArnthorssondeCODE genetics/Amgen, Reykjavik, Iceland.
Edda L StyrmisdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Julius GudmundssondeCODE genetics/Amgen, Reykjavik, Iceland.
Gerdur M GrondalFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Kristjan SteinssonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Lars AlfredssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Johan AsklingDepartment of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Rafn BenediktssonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-2954-9801
Ragnar BjarnasonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Arni J GeirssonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Bjorn GudbjornssonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Hallgrimur GudjonssonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Haukur HjaltasonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Astradur B HreidarssonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Lars KlareskogDepartment of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Ingrid KockumDepartment of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-0867-4726
Helga KristjansdottirCenter for Rheumatology Research, Landspitali, The National University Hospital of Iceland, Reykjavik, Iceland.
Thorvardur J LoveFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Bjorn R LudvikssonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Tomas OlssonDepartment of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Pall T OnundarsonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Kjartan B OrvarFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Leonid PadyukovDepartment of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2950-5670
Bardur SigurgeirssonFaculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
Vinicius TragantedeCODE genetics/Amgen, Reykjavik, Iceland.
Kristbjorg BjarnadottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Thorunn RafnardeCODE genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-0491-7046
Gisli MassondeCODE genetics/Amgen, Reykjavik, Iceland.
Patrick SulemdeCODE genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7123-6123
Daniel F GudbjartssondeCODE genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Pall MelsteddeCODE genetics/Amgen, Reykjavik, Iceland.
Gudmar ThorleifssondeCODE genetics/Amgen, Reykjavik, Iceland.
Gudmundur L NorddahldeCODE genetics/Amgen, Reykjavik, Iceland.
Unnur ThorsteinsdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Ingileif JonsdottirdeCODE genetics/Amgen, Reykjavik, Iceland.
Kari StefanssondeCODE genetics/Amgen, Reykjavik, Iceland. kstefans@decode.is.ORCID http://orcid.org/0000-0003-1676-864X
deCODE Genetics (Iceland) · ISUniversity of Iceland · ISKarolinska Institutet · SENational University Hospital of Iceland · IS
Funding
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
Abstract
Autoimmune thyroid disease is the most common autoimmune disease and is highly heritable
Indexed as
LigandsMutationAllelesAutoimmune DiseasesCodon, NonsenseDatabases, Factualfms-Like Tyrosine Kinase 3Genetic Predisposition to DiseaseGenome-Wide Association StudyGerm-Line MutationHumansIcelandIntronsLeukemia, Myeloid, AcuteLoss of Function MutationRNA Splice SitesCodon, NonsenseFLT3 protein, humanfms-Like Tyrosine Kinase 3LigandsRNA Splice Sites
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.