ArticleScientific reports2020
Safety Assessment of a Nham Starter Culture Lactobacillus plantarum BCC9546 via Whole-genome Analysis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
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- Assessing the Probiotic Properties and safety of Limosilactobacillus reuteri LP4 Isolated from Apis cerana Based on Whole Genome and Phenotype Analyses.Probiotics and antimicrobial proteins · 2026Article
- Hybrid genome assembly and comprehensive genomic analysis of Lactiplantibacillus pentosus LP309 reveal its probiotic and technological potential.BMC genomics · 2026Article
- Exosome-like Nanovesicles fromMolecules (Basel, Switzerland) · 2026Article
- Probiotic Characteristics and Whole Genome Analysis of Lactiplantibacillus plantarum PM8 from Giant Panda (Ailuropoda melanoleuca) Milk.Probiotics and antimicrobial proteins · 2025Article
- Genomic Analysis for the Safety Assessment of a Potential Probiotic Strain Pediococcus pentosaceus BBS1 Isolated From Lao Fermented Bamboo Shoots (Nor Mai Som).MicrobiologyOpen · 2025Article
- Genomic Insights into the Probiotic Functionality and Safety ofFoods (Basel, Switzerland) · 2025Article
- Comprehensive in vitro and whole-genome characterization of probiotic properties in Pediococcus acidilactici P10 isolated from Iranian broiler chicken.Scientific reports · 2025Article
- Genomic insights and metabolic profiling of gut commensal Luoshenia tenuis at strain level.NPJ biofilms and microbiomes · 2025Article
- In Vitro Evaluation of the Probiotic Properties and Whole Genome Sequencing ofMicroorganisms · 2025Article
- Risk analysis approaches for microbial ingredients in microbial-based cleaning products.Risk analysis : an official publication of the Society for Risk Analysis · 2025Article
- Functional genomic insights into Floricoccus penangensis ML061-4 isolated from leaf surface of Assam tea.Scientific reports · 2025Article
- Comprehensive genomic assessment of available probiotics in India: A framework for safety and functionality evaluation.Bioinformation · 2025Article
- Evaluating the safety and efficacy ofFrontiers in microbiology · 2025Article
- Comprehensive Safety Assessment ofCurrent issues in molecular biology · 2024Article
- Probiotic Insights from the Genomic Exploration ofFoods (Basel, Switzerland) · 2024Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The safety of microbial cultures utilized for consumption is vital for public health and should be thoroughly assessed. Although general aspects on the safety assessment of microbial cultures have been suggested, no methodological detail nor procedural guideline have been published. Herein, we propose a detailed protocol on microbial strain safety assessment via whole-genome sequence analysis. A starter culture employed in traditional fermented pork production, nham, namely Lactobacillus plantarum BCC9546, was used as an example. The strain's whole-genome was sequenced through several next-generation sequencing techniques. Incomplete plasmid information from the PacBio sequencing platform and shorter chromosome size from the hybrid Oxford Nanopore-Illumina platform were noted. The methods for 1) unambiguous species identification using 16S rRNA gene and average nucleotide identity, 2) determination of virulence factors and undesirable genes, 3) determination of antimicrobial resistance properties and their possibility of transfer, and 4) determination of antimicrobial drug production capability of the strain were provided in detail. Applicability of the search tools and limitations of databases were discussed. Finally, a procedural guideline for the safety assessment of microbial strains via whole-genome analysis was proposed.
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