SynthesisNature communications2020
Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization.International journal of cancer · 2025Pooled it
- New-Onset Type 2 Diabetes Mellitus and Cancer Risk: A Matched Cohort Study in China Kadoorie Biobank.International journal of cancer · 2026Article
- Polygenic scores for risk of pancreatic ductal adenocarcinoma: evaluation of novel and published models.NPJ precision oncology · 2026Article
- Pancreatic cancer.Nature reviews. Disease primers · 2026Review
- Associations Between Obesity, Diabetes Mellitus, and Pancreatic Cancer in the Japanese Population: A Mendelian Randomization Study.Cancer science · 2026Article
- Novel Genetic Risk Loci for Pancreatic Ductal Adenocarcinoma Identified in a Genome-wide Study of African Ancestry Individuals.medRxiv : the preprint server for health sciences · 2026Article
- Causal association of type 1 diabetes with pancreatic cancer: a multi-ancestry Mendelian randomization study.Archives of medical science : AMS · 2026Article
- The Burden of Pancreatic Cancer in Five East Asian Countries From 1990 to 2021 and Its Prediction up to 2036: A Systemic Analysis of the Global Burden of Diseases Study 2021.Cancer medicine · 2025Article
- The immune-related prognostic gene AIM2 promotes pancreatic cancer progression via inflammasome.Scientific reports · 2025Article
- Amyotrophic Lateral Sclerosis and Risk of Common Cancer: Mendelian Randomization Interrogation of Causality and Mediation.Phenomics (Cham, Switzerland) · 2025Article
- Leveraging genome-wide association studies to better understand the etiology of cancers.Cancer science · 2025Review
- Integrative Analysis of eQTL Genes Reveals Key Biomarkers and Mechanisms for Early Diagnosis of Pancreatic Ductal Adenocarcinoma.Cancer informatics · 2025Article
- Understanding familial risk of pancreatic ductal adenocarcinoma.Familial cancer · 2024Review
- Genetically predicted gut bacteria, circulating bacteria-associated metabolites and pancreatic ductal adenocarcinoma: a Mendelian randomisation study.Scientific reports · 2024Article
- Analysis of Pancreatic Cancer Genetic Risk Factors in a Multi-Ethnic Population Sample.World journal of oncology · 2024Article
- Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Circulating pancreatic enzyme levels are a causal biomarker of type 1 diabetes.medRxiv : the preprint server for health sciences · 2024Article
- Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk.Human genomics · 2024Article
- Candidate Biomarkers for Targeting in Type 1 Diabetes; A Bioinformatic Analysis of Pancreatic Cell Surface Antigens.Cell journal · 2024Article
- Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.Seminars in immunopathology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
86 authors at 20 institutions in 2 countries.
Yingsong Lin *Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan. linys@aichi-med-u.ac.jp.ORCID http://orcid.org/0000-0003-0214-3649
Masahiro Nakatochi *Division of Public Health Informatics, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan. mnakatochi@met.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0002-1838-4837
Yasuyuki Hosono *Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan.
Hidemi Ito *Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan.ORCID http://orcid.org/0000-0002-8023-4581
Yoichiro KamataniLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Akihito InokoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan.ORCID http://orcid.org/0000-0002-6739-2948
Hiromi SakamotoGenetics Division, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.
Fumie KinoshitaData Science Division, Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, 461-8673, Japan.
Yumiko KobayashiData Science Division, Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital, Nagoya, 461-8673, Japan.
Hiroshi IshiiChiba Cancer Center, Chiba, 260-8717, Japan.
Masato OzakaDepartment of Hepato-biliary-pancreatic Medicine, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan.
Takashi SasakiDepartment of Hepato-biliary-pancreatic Medicine, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan.
Masato MatsuyamaDepartment of Hepato-biliary-pancreatic Medicine, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan.
Naoki SasahiraDepartment of Hepato-biliary-pancreatic Medicine, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan.
Manabu MorimotoDepartment of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center, Yokohama, 241-8515, Japan.
Satoshi KobayashiDepartment of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center, Yokohama, 241-8515, Japan.
Taito FukushimaDepartment of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center, Yokohama, 241-8515, Japan.
Makoto UenoDepartment of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center, Yokohama, 241-8515, Japan.ORCID http://orcid.org/0000-0003-4480-0029
Shinichi OhkawaDepartment of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology Division, Kanagawa Cancer Center, Yokohama, 241-8515, Japan.
Naoto EgawaDepartment of Gastroenterology, Tokyo Metropolitan Hiroo Hospital, Tokyo, 150-0013, Japan.
Sawako KurumaDepartment of Gastroenterology, Tokyo Metropolitan Komagome Hospital, Tokyo, 113-8677, Japan.
Mitsuru MoriHokkaido Chitose College of Rehabilitation, Hokkaido, 066-0055, Japan.
Haruhisa NakaoDivision of Hepatology and Pancreatology, Aichi Medical University School of Medicine, Nagakute, 480-1195, Japan.
Yasushi AdachiSapporo Shirakabadai Hospital, Sapporo, 062-0052, Japan.ORCID http://orcid.org/0000-0002-2530-1745
Masumi OkudaDepartment of Pediatrics, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
Takako OsakiDepartment of Infectious Diseases, Kyorin University School of Medicine, Tokyo, 181-8611, Japan.ORCID http://orcid.org/0000-0002-6430-4666
Shigeru KamiyaDepartment of Infectious Diseases, Kyorin University School of Medicine, Tokyo, 181-8611, Japan.
Chaochen WangDepartment of Public Health, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan.ORCID http://orcid.org/0000-0001-5533-1497
Kazuo HaraDepartment of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, 464-8681, Japan.
Yasuhiro ShimizuDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, 464-8681, Japan.
Tatsuo MiyamotoDepartment of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, 734-8553, Japan.ORCID http://orcid.org/0000-0002-1097-0647
Yuko HayashiDivision of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan.
Hiromichi EbiDivision of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan.
Tomohiro KohmotoDepartment of Human Genetics, Tokushima University Graduate School of Medicine, Tokushima, 770-8503, Japan.
Issei ImotoDivision of Molecular Genetics, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan.
Yumiko KasugaiDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan.ORCID http://orcid.org/0000-0003-4764-4455
Yoshinori MurakamiDivision of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0002-2826-4396
Masato AkiyamaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Kazuyoshi IshigakiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.ORCID http://orcid.org/0000-0003-2881-0657
Koichi MatsudaGraduate School of Frontier Sciences, The University of Tokyo, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0001-7292-2686
Makoto HirataDivision of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0002-9994-9958
Kazuaki ShimadaDepartment of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, 104-0045, Japan.
Takuji OkusakaDepartment of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, 104-0045, Japan.ORCID http://orcid.org/0000-0003-1729-807X
Takahisa KawaguchiCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Meiko TakahashiCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Yoshiyuki WatanabeDepartment of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Kiyonori KurikiLaboratory of Public Health, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan.
Aya KadotaDepartment of Public Health, Shiga University of Medical Science, Otsu, 520-2192, Japan.
Rieko OkadaDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.ORCID http://orcid.org/0000-0002-6206-2501
Haruo MikamiCancer Prevention Center, Chiba Cancer Center Research Institute, Chiba, 260-8717, Japan.
Toshiro TakezakiDepartment of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544, Japan.
Sadao SuzukiDepartment of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, 467-8601, Japan.
Taiki YamajiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, 104-0045, Japan.
Motoki IwasakiDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, 104-0045, Japan.
Norie SawadaDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, 104-0045, Japan.ORCID http://orcid.org/0000-0002-9936-1476
Atsushi GotoDivision of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, 104-0045, Japan.
Kengo KinoshitaTohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.ORCID http://orcid.org/0000-0003-3453-2171
Nobuo FuseTohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.ORCID http://orcid.org/0000-0003-0237-4746
Fumiki KatsuokaTohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan.
Atsushi ShimizuIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, 028-3694, Japan.ORCID http://orcid.org/0000-0001-8307-2461
Satoshi S NishizukaIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, 028-3694, Japan.ORCID http://orcid.org/0000-0001-9178-790X
Kozo TannoIwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, 028-3694, Japan.
Ken SuzukiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.ORCID http://orcid.org/0000-0003-1065-3593
Yukinori OkadaLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.ORCID http://orcid.org/0000-0002-0311-8472
Momoko HorikoshiLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
Toshimasa YamauchiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.ORCID http://orcid.org/0000-0003-4827-6404
Takashi KadowakiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.ORCID http://orcid.org/0000-0002-5428-3582
Herbert YuUniversity of Hawaii Cancer Center, Honolulu, HI, 96813, USA.ORCID http://orcid.org/0000-0003-3950-4815
Jun ZhongLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0002-3700-9434
Laufey T AmundadottirLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0003-1859-8971
Yuichiro DokiDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
Hideshi IshiiDepartment of Medical Data Science, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
Hidetoshi EguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
David BogumilDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeless, CA, 90033, USA.ORCID http://orcid.org/0000-0002-5001-1088
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeless, CA, 90033, USA.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, 96813, USA.
Masaki MoriDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Harvey RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, 06520, USA.
Veronica W SetiawanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeless, CA, 90033, USA.
Shoichiro TsuganeCenter for Public Health Sciences, National Cancer Center, Tokyo, 104-0045, Japan.ORCID http://orcid.org/0000-0003-4105-2774
Kenji WakaiDepartment of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Teruhiko YoshidaGenetics Division, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.
Fumihiko MatsudaCenter for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.ORCID http://orcid.org/0000-0002-0095-2322
Shogo KikuchiDepartment of Public Health, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan.
Keitaro MatsuoDivision of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, 464-8681, Japan. kmatsuo@aichi-cc.jp.ORCID http://orcid.org/0000-0003-1761-6314
Aichi Cancer Center · JPRIKEN Center for Integrative Medical Sciences · JPAichi Medical University · JPKanagawa Prefectural Hospital Organization · JPThe University of Tokyo · JPThe Cancer Institute Hospital · JPChiba Cancer Center · JPIwate Medical University · JPKyoto University · JPKyushu University · JPNagoya University · JPTohoku University · JPUniversity of Southern California · USKyorin University · JPNagoya University Hospital · JPNational Institutes of Health · USThe University of Osaka · JPUniversity of Hawaiʻi at Mānoa · USHiroshima University · JPHyogo Medical University · JP
Funding
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MUnderstanding Ethnic Differences in Cancer: The Multiethnic Cohort StudyUM1CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HENDERSON, BRIAN E, LE MARCHAND, LOIC · 2012 to 2014
$11.3MCase Control Study of Pancreas Cancer in Shanghai, ChinaR01CA114421 · NCI · YALE UNIVERSITY · PI RISCH, HARVEY A · 2007 to 2012
$2.6MInvestigating the cause of racial/ethnic disparity in pancreatic cancer incidenceR01CA209798 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SETIAWAN, VERONICA WENDY · 2017 to 2020
$1.8MNCI NIH HHS R01 CA114421NCI NIH HHS R01 CA209798NCI NIH HHS U01 CA164973NCI NIH HHS UM1 CA164973
Abstract
Pancreatic cancer is the fourth leading cause of cancer-related deaths in Japan. To identify risk loci, we perform a meta-analysis of three genome-wide association studies comprising 2,039 pancreatic cancer patients and 32,592 controls in the Japanese population. Here, we identify 3 (13q12.2, 13q22.1, and 16p12.3) genome-wide significant loci (P < 5.0 × 10
Indexed as
Asian PeopleCell Line, TumorDatabases, GeneticGenetic LociGenetic PleiotropyGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeGPI-Linked ProteinsHumansPancreatic NeoplasmsPolymorphism, Single NucleotideGP2 protein, humanGPI-Linked Proteins
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