Evidence map›Paper›PMID 32581161›Full record

ArticleInternal medicine (Tokyo, Japan)2020

Coexisting TIF1γ-positive Primary Pulmonary Lymphoepithelioma-like Carcinoma and Anti-TIF1γ Antibody-positive Dermatomyositis.

Yu Nakanishi, Kakuhiro Yamaguchi, Yusuke Yoshida, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Taku Nakashima, Shintarou Miyamoto, Hiroshi Iwamoto, Shintaro Hirata and 4 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Yu NakanishiDepartment of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
Kakuhiro YamaguchiDepartment of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
Yusuke YoshidaDepartment of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Shinjiro SakamotoDepartment of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
Yasushi HorimasuDepartment of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
Takeshi MasudaDepartment of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
Taku NakashimaDepartment of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
Shintarou MiyamotoDepartment of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
Hiroshi IwamotoDepartment of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
Shintaro HirataDepartment of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Kazunori FujitakaDepartment of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
Hironobu HamadaDepartment of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
Eiji SugiyamaDepartment of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Japan.
Noboru HattoriDepartment of Respiratory Internal Medicine, Hiroshima University Hospital, Japan.
Hiroshima University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-transcriptional intermediary factor 1γ (anti-TIF1γ) antibody-positive dermatomyositis (DM) is strongly associated with cancer, although the mechanism of action is still unclear. We herein describe the first known case of an 80-year-old woman diagnosed with TIF1γ-positive primary pulmonary lymphoepithelioma-like carcinoma (LELC) coexisting with anti-TIF1γ antibody-positive DM. The diagnosis of LELC can only be made by a surgical lung biopsy, and not by a computed tomography-guided biopsy, because of heavy lymphocytic infiltration. This instructive case reaffirmed the importance of active screening for malignancy in patients with anti-TIF1γ antibody-positive DM. Interestingly, the results also suggested that the strong relationship which exists between anti-TIF1γ antibody-positive DM and cancer is potentially caused by tumor-derived TIF1γ.

Indexed as

Aged, 80 and overAutoantibodiesBiopsyCarcinomaDermatomyositisFemaleHumansLung NeoplasmsTranscription FactorsAutoantibodiesTranscription FactorsTRIM33 protein, humananti-transcriptional intermediary factor 1γdermatomyositisEpstein-Barr virusprimary lung lymphoepithelial carcinoma

Identifiers

PMID32581161
PMCPMC7662058
OpenAlexW3036664170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.