Evidence map›Paper›PMID 32581140›Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2020

Desquamative interstitial pneumonia: a systematic review of its features and outcomes.

Merel E Hellemons, Catharina C Moor, Jan von der Thüsen, Mariska Rossius, Arlette Odink, Laila Haugen Thorgersen, Johny Verschakelen, Wim Wuyts, Marlies S Wijsenbeek, Elisabeth Bendstrup

Erratum issuedAbstract readSystematic Review
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review of research on pulmonary cysts in sjögren's syndrome.Journal of cardiothoracic surgery · 2025
    Review
  6. Article
  7. Desquamative interstitial pneumonia: A case report.Experimental and therapeutic medicine · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Lethal eosinophilic crystalline pneumonia in mice expressing a stabilized Csf2 mRNA.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Tomographic pleuropulmonary manifestations in rheumatoid arthritis: a pictorial essay.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2023
    Article
  16. Glucocorticoid therapy in respiratory illness: bench to bedside.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2022
    Review
  17. Review
  18. Sex and gender in interstitial lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Merel E HellemonsDept of Interstitial Lung Disease, Erasmus Medical Center, Rotterdam, The Netherlands.
Catharina C MoorDept of Interstitial Lung Disease, Erasmus Medical Center, Rotterdam, The Netherlands.
Jan von der ThüsenDept of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.
Mariska RossiusDept of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Arlette OdinkDept of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Laila Haugen ThorgersenDept of Respiratory Diseases, Nastved Hospital, Nastved, Denmark.
Johny VerschakelenDept of Radiology, University Hospital Leuven, Leuven, Belgium.
Wim WuytsUnit of Interstitial Lung Disease, University Hospital Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0001-9648-3497
Marlies S WijsenbeekDept of Interstitial Lung Disease, Erasmus Medical Center, Rotterdam, The Netherlands m.wijsenbeek-lourens@erasmusmc.nl.
Elisabeth BendstrupDept of Respiratory Diseases and Allergy, Center for Rare Lung Diseases, Aarhus University Hospital, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDesquamative Interstitial Pneumonia (DIP) is a rare form of idiopathic interstitial pneumonia (IIP). Data on clinical features, aetiology, prognosis and effect of treatment strategies are limited. We aimed to collect all published cases to better characterise DIP.

methodsA systematic literature search was performed for all original cases of adult patients with histopathologically-confirmed DIP. Individual patient data were extracted and summarised.

resultsWe included 68 individual cases and 13 case series reporting on 294 cases. Most common presenting symptoms were dyspnoea and cough. Pulmonary function showed a restrictive pattern (71%) with decreased diffusion capacity. We found a high incidence (81%) of ever smoking in patients with DIP and 22% of patients had other (occupational) exposures. Characteristic features on high-resolution computed tomography (HRCT) scan were bilateral ground-glass opacities with lower lobe predominance (92%). Treatment and duration of treatment widely varied. Initial response to treatment was generally good, but definitely not uniformly so. A significant proportion of patients died (25% of individual cases) or experienced a relapse (18% of individual cases).

conclusionDIP remains an uncommon disease, frequently but not always related to smoking or other exposures. Furthermore, DIP behaves as a progressive disease more often than generally thought, possibly associated with different underlying aetiology.

Indexed as

AdultDiagnostic ImagingHumansIdiopathic Interstitial PneumoniasPrognosisRespiratory Function TestsRisk Factors

Identifiers

PMID32581140
PMCPMC9488565

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.