Evidence map›Paper›PMID 32581135›Full record

ReviewScience translational medicine2020

Biology of antimicrobial resistance and approaches to combat it.

Sarah M Schrader, Julien Vaubourgeix, Carl Nathan

Abstract readReview
In one paragraph

Review in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Usnic Acid Derivatives as Inhibitors ofInternational journal of molecular sciences · 2026
    Article
  7. Article
  8. Article
  9. Genomic Epidemiology ofMicroorganisms · 2026
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sarah M SchraderDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0003-4141-531X
Julien VaubourgeixMRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0003-4872-0464
Carl NathanDepartment of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA. cnathan@med.cornell.edu.ORCID 0000-0002-7744-8896

Funding

Weill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1M
Viable but Nonculturable MtbU19AI111143 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI FITZGERALD, DANIEL W, GLICKMAN, MICHAEL S · 2014 to 2020
$48.6M
Molecular mechanisms of persistence in mycobacteriaF30AI140623 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHRADER, SARAH M. · 2018 to 2022
$194k
Medical Research Council MR/P028225/1NIAID NIH HHS F30 AI140623NIAID NIH HHS U19 AI111143NIGMS NIH HHS T32 GM007739
6 · The paper itself

Abstract

Insufficient development of new antibiotics and the rising resistance of bacteria to those that we have are putting the world at risk of losing the most widely curative class of medicines currently available. Preventing deaths from antimicrobial resistance (AMR) will require exploiting emerging knowledge not only about genetic AMR conferred by horizontal gene transfer or de novo mutations but also about phenotypic AMR, which lacks a stably heritable basis. This Review summarizes recent advances and continuing limitations in our understanding of AMR and suggests approaches for combating its clinical consequences, including identification of previously unexploited bacterial targets, new antimicrobial compounds, and improved combination drug regimens.

Indexed as

Anti-Infective AgentsDrug Resistance, BacterialAnti-Bacterial AgentsBacteriaBiologyAnti-Bacterial AgentsAnti-Infective Agents

Identifiers

PMID32581135
PMCPMC8177555

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.