ArticleProceedings of the National Academy of Sciences of the United States of America2020
The transition to family caregiving and its effect on biomarkers of inflammation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Gender differences and psychosocial stress in upper respiratory tract infections: insights from healthy and hematological cancer cohorts.BMC public health · 2026Article
- Supporting family caregivers: Variations in caregiving among families managing chronic health conditions.The American psychologist · 2025Article
- Longitudinal impact of transition to caregiving on cognitive functioning: a matched case-control study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Relationship between cellular aging, perceived stress, and cardiometabolic disease risk in Black family caregivers of persons with dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Longitudinal associations in dementia family caregivers of ambivalent feelings and disruptive behaviors with C-reactive protein, interleukin-6, and D-dimer.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- 2024 Alzheimer's disease facts and figures.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Association between psychosocial factors and C-reactive protein across income, race, and sex.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- Understanding the health effects of caregiving stress: New directions in molecular aging.Ageing research reviews · 2023Review
- Psychobiological effects of an eHealth psychoeducational intervention to informal caregivers of persons with dementia: a pilot study during the COVID-19 pandemic in Italy.Aging clinical and experimental research · 2023Article
- Caregiver Burdens, Health Risks, Coping and Interventions among Caregivers of Dementia Patients: A Review of the Literature.Internal medicine (Tokyo, Japan) · 2023Review
- The role of caregiving in cognitive function and change: The REGARDS study.Psychology and aging · 2023Article
- Associations of perceived stress, depressive symptoms, and caregiving with inflammation: a longitudinal study.International psychogeriatrics · 2023Article
- Strengths-building through life purpose, self-care goal setting and social support: Study protocol for Caregiver Support.Contemporary clinical trials communications · 2022Article
- The Differential Effects of Caregiving Intensity on Overnight Hospitalization.Western journal of nursing research · 2022Article
- Sleep Quality Reports From Family Caregivers and Matched Non-caregiving Controls in a Population-Based Study.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022Article
- Association between inflammatory cytokines and caregiving distress in family caregivers of cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Article
- Effects of Transitions to Family Caregiving on Well-Being: A Longitudinal Population-Based Study.Journal of the American Geriatrics Society · 2020Article
- Evaluation of a Photo Captioning Cognitive Empathy Intervention for Dementia Caregivers.Clinical gerontologistArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Chronic stress has been widely proposed to increase systemic inflammation, a pathway that may link stress with a heightened risk for many diseases. The chronic stress-inflammation relationship has been challenging to study in humans, however, and family caregiving has been identified as one type of stressful situation that might lead to increased inflammation. Previous studies of caregiving and inflammation have generally used small convenience samples, compared caregivers with poorly characterized control participants, and assessed inflammation only after caregivers provided care for extended periods of time. In the current project, changes over a 9-y period were examined on six circulating biomarkers of inflammation for 480 participants from a large population-based study. All participants reported no involvement in caregiving prior to the first biomarker assessment, and 239 participants then took on extensive and prolonged family caregiving responsibilities at some point prior to the second biomarker assessment. Incident caregivers were individually matched on multiple demographic and health history variables with participants who reported no caregiving responsibilities. Of the six biomarkers examined, only tumor necrosis factor alpha receptor 1 showed a significantly greater increase in caregivers compared with controls. This effect was small (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.