Evidence map›Paper›PMID 32581106›Full record

ArticleJournal of virology2020

Hypervariable Domain of nsP3 of Eastern Equine Encephalitis Virus Is a Critical Determinant of Viral Virulence.

Chetan D Meshram, Nikita Shiliaev, Elena I Frolova, Ilya Frolov

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Role(s) of G3BPs in Human Pathogenesis.The Journal of pharmacology and experimental therapeutics · 2023
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Alphavirus Virulence Determinants.Pathogens (Basel, Switzerland) · 2021
    Review
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chetan D MeshramDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Nikita ShiliaevDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Elena I FrolovaDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0001-6523-9336
Ilya FrolovDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA ivfrolov@uab.edu.ORCID 0000-0002-8548-2517
University of Alabama at Birmingham · US

Funding

Mechanistic role of ns2 protein in evasion of innate immune response by alphavirusesR01AI133159 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FROLOVA, ELENA I · 2017 to 2021
$3.0M
Alphavirus nsP3 protein: roles of intrinsically disordered region in virus replication and pathogenesisR01AI118867 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FROLOVA, ELENA I · 2015 to 2019
$1.8M
Mechanism of alphavirus packaging: designing of pseudoinfectious virusesR01AI095449 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FROLOV, ILYA V. · 2012 to 2016
$1.8M
Mechanistic understanding of SH3 domain-containing protein function in alphavirus replicationR21AI146969 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FROLOV, ILYA V. · 2019 to 2020
$401k
NIAID NIH HHS R01 AI095449NIAID NIH HHS R01 AI118867NIAID NIH HHS R01 AI133159NIAID NIH HHS R21 AI146969
6 · The paper itself

Abstract

Eastern equine encephalitis virus (EEEV) is the most pathogenic member of the

Indexed as

AnimalsAntibodies, NeutralizingBinding SitesCapsid ProteinsCell LineEncephalitis Virus, Eastern EquineEncephalomyelitis, EquineMiceMutationVaccines, AttenuatedViral Nonstructural ProteinsVirulenceVirulence FactorsVirus ReplicationAntibodies, NeutralizingCapsid Proteinsnsp3 protein, alphavirusVaccines, AttenuatedViral Nonstructural ProteinsVirulence Factorsalphaviruscapsid proteinEastern equine encephalitis virusFXRG3BPintrinsically disorderedneurovirulencensP3vaccineviral replication

Identifiers

PMID32581106
PMCPMC7431797
OpenAlexW3036205100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.