Observational studyBMJ open2020
Association between fasting blood glucose and outcomes and mortality in acute ischaemic stroke patients with diabetes mellitus: a retrospective observational study in Wuhan, China.
Observational study in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Diagnostic utility of fasting versus non-fasting blood glucose: contextualising testing strategies-a narrative review.Diabetology & metabolic syndrome · 2026Review
- Superlearner can predict in-hospital mortality risk in critically ill patients with ischemic stroke: development and international validation.BMC medical informatics and decision making · 2026Article
- Integrating GLP-1 Receptor Agonists into Modern Stroke Prevention: Evidence, Mechanisms, and Clinical Consideration-A Narrative Review.Biomedicines · 2026Review
- Associations Between the Modified Cardiometabolic Index and Stroke in Patients With Different Glucose Metabolism Statuses: Evidence From a Nationally Representative Survey.Reviews in cardiovascular medicine · 2026Article
- Epidemiological and clinical profile of ischemic, hemorrhagic, and mixed strokes in Sikasso, Mali: a prospective cross-sectional study.The Pan African medical journal · 2026Article
- Evaluation of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) as prognostic markers in ischemic stroke of diabetic patients: A cross-sectional analysis.Journal of family medicine and primary care · 2025Article
- Elevated phenylacetylglutamine caused by gut dysbiosis associated with type 2 diabetes increases neutrophil extracellular traps formation and exacerbates brain infarction.Clinical science (London, England : 1979) · 2025Article
- Article
- The Association of Systemic Inflammatory Response Index and Neutrophil-to-High-Density Lipoprotein Ratio Mediated by Fasting Blood Glucose with 90-Day Prognosis in Acute Ischemic Stroke Patients.Neuroepidemiology · 2025Observational
- Correlation between the hemoglobin-to-hematocrit ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study.Frontiers in neurology · 2025Article
- Six-month survival and predictors of mortality after ischemic stroke: A prospective cohort study in Iran.ARYA atherosclerosis · 2025Article
- Review
- Deep medullary veins as an important imaging indicator of poor prognosis in acute ischemic stroke: a retrospective cohort survey.Quantitative imaging in medicine and surgery · 2023Article
- Differences in risk factors and outcome after acute stroke in patients with tandem occlusion and those with isolated intracranial occlusion after endovascular treatment.Neurosurgical review · 2023Article
- Article
- Stroke-associated infection in patients with co-morbid diabetes mellitus is associated with in-hospital mortality.Frontiers in aging neuroscience · 2022Article
- Fasting Blood-Glucose Level and Clinical Outcome in Anterior Circulation Ischemic Stroke of Different Age Groups After Endovascular Treatment.Neuropsychiatric disease and treatment · 2022Article
- Outcomes of Ischemic Stroke and Associated Factors Among Elderly Patients With Large-Artery Atherosclerosis: A Hospital-Based Follow-Up Study in China.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the predictive value of fasting blood glucose (FBG) on unfavourable outcomes and mortality in diabetes mellitus (DM) patients after acute ischaemic stroke (AIS). STUDY
designA hospital-based observational cohort study was conducted. Clinical data, including sex, age, body mass index, vascular risk factors and systolic/diastolic blood pressure, were routinely collected. National Institutes of Health Stroke Scale score was used to assess stroke severity on admission. FBG was determined on the first day after fasting for at least 8 hours. The modified Rankin Scale was used to assess functional outcome at 90 days: 3-6, unfavourable outcome and 6, death.
settingRenmin Hospital of Wuhan University, Wuhan, China.
participantsPatients who had AIS with DM, who were consecutively admitted within 24 hours of onset from January 2018 to June 2019.
resultsFor the 568 patients, the median age was 65 years (IQR, 55-74 years). There were 377 (66.4%) men. The median FBG values were 7.37 mmol/L (IQR, 5.99-10.10 mmol/L), and the median glycated haemoglobin (HbA1c) values were 6.6 (IQR, 5.8-8.3). Multivariable logistic and Cox regression analysis of confounding factors showed that FBG at the time of admission was an independent predictor of unfavourable outcome (OR, 1.25 (1.14-1.37); p<0.0001) and mortality (HR, 1.10 (1.03-1.15); p<0.05) at 90 days after onset. Time to death was analysed by Kaplan-Meier curves based on FBG quartiles. The risk of death in the two highest quartile groups (FBG, 7.38-10.10 mmol/L; FBG, ≥10.11 mmol/L) was significantly higher than that in the two lowest quartile groups (FBG, ≤6.00 mmol/L; FBG, 6.01-7.37 mmol/L; p<0.0001).
conclusionsHigher FBG levels are associated with unfavourable outcomes and mortality in Chinese patients who had AIS with DM. Our data contribute to the knowledge regarding the relationship between FBG and prognosis in patients with DM who had AIS.
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