Evidence map›Paper›PMID 32580987›Full record

ArticleBMJ open2020

Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant microbiome and adverse health outcomes - a prospective cohort study among children born at term.

Maryse Volery, Valentin Scherz, William Jakob, Diane Bandeira, Vanessa Deggim-Messmer, Anna Lauber-Biason, Johannes Wildhaber, Laurent Falquet, Nigel Curtis, Petra Zimmermann

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04091282 (Antibiotic-induced Disruption of the Maternal and Infant Microbiota and Adverse Health Outcomes - The ABERRANT Study), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04091282 unknown statusnot on this map

Antibiotic-induced Disruption of the Maternal and Infant Microbiota and Adverse Health Outcomes - The ABERRANT Study

TypeobservationalSponsorUniversity of FribourgRan2020 to 2025Enrolled400ConditionsMicrobiota, Antibiotic DisruptionArmsNo intervention
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Maryse VoleryFaculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Valentin ScherzInstitute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland.
William JakobMicrobiology Laboratory, Fribourg Hospital HFR, Fribourg, Switzerland.
Diane BandeiraMicrobiology Laboratory, Fribourg Hospital HFR, Fribourg, Switzerland.
Vanessa Deggim-MessmerMicrobiology Laboratory, Fribourg Hospital HFR, Fribourg, Switzerland.
Anna Lauber-BiasonFaculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Johannes WildhaberFaculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Laurent FalquetDepartment of Biology, University of Fribourg, Fribourg, Switzerland.
Nigel CurtisDepartment of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia.
Petra ZimmermannFaculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland petra.zimmermann@unifr.ch.ORCID 0000-0002-2388-4318
University of Fribourg · CHRoyal Children's Hospital · AUSIB Swiss Institute of Bioinformatics · CHUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Antibiotics cause profound changes in the microbiome. However, the effect of intrapartum and early-life antibiotics on the maternal intestinal and breast milk microbiome, and the infant oral and intestinal microbiome, and whether effects are only short term or persist long term remain uncertain. METHODS AND ANALYSES: In this prospective cohort study, we will use metagenomic sequencing to determine: (1) the effect of intrapartum antibiotics on the composition of the breast milk, and the infant oral and intestinal microbiome, including the development and persistence of antibiotic resistance; (2) the effect of antibiotic exposure in the first year of life on the composition of the infant oral and intestinal microbiome, including the development and persistence of antibiotic resistance; (3) the effect of disruption of the infant oral and intestinal microbiome on health outcomes and (4) the compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. ETHICS AND DISSEMINATION: The ABERRANT study has been approved by the commission cantonale d'éthique de la recherche sur l'être humain (CER-VD) du Canton de Vaud (#2019-01567). Outcomes will be disseminated through publication and will be presented at scientific conferences. TRIAL REGISTRATION NUMBER: NCT04091282.

Indexed as

Anti-Bacterial AgentsGastrointestinal MicrobiomePrenatal Exposure Delayed EffectsClinical Studies as TopicDrug Resistance, BacterialEczemaFemaleHumansHypersensitivityInfantInfant, NewbornMetagenomicsMilk, HumanOtitis MediaPregnancyProspective StudiesAnti-Bacterial Agentsimmunologymicrobiologymolecular diagnosticsneonatologypaediatric infectious disease & immunisation

Identifiers

PMID32580987
PMCPMC7312317
OpenAlexW3035984817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.