Observational studyThe British journal of ophthalmology2021
Reduced vessel density in deep capillary plexus correlates with retinal layer thickness in choroideremia.
Observational study in The British journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Evaluation of retinal microvasculature in exotropia with abnormal binocular vision by optical coherence tomography angiography.BMC ophthalmology · 2023Trial
- Lycium barbarum glycopeptide confers neuroprotection in chronic ocular hypertensive rats: a study investigating visual function, retinal structure, microcirculation, and pyroptosis.Frontiers in pharmacology · 2026Article
- Optical coherence tomography angiography findings in patients with sudden sensorineural hearing loss.Scientific reports · 2025Article
- Rekindling Vision: Innovative Strategies for Treating Retinal Degeneration.International journal of molecular sciences · 2025Review
- Macular vessel density in patients with refractory diabetic macular edema in different stages of nonproliferative diabetic retinopathy.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Article
- Prevalence of Age-Related Macular Degeneration in the United States: A Medicare-Based Analysis from 2014 to 2021.Ophthalmic research · 2025Article
- The effect of heart rate variability on the choroidal vascularity of the optical coherence tomography and angiography in central serous chorioretinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Loss of REP1 impacts choroidal melanogenesis and vasculogenesis in choroideremia.Biochimica et biophysica acta. Molecular basis of disease · 2024Article
- Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease.International journal of ophthalmology · 2024Article
- Optical coherence tomography angiography in Bietti crystalline dystrophy.European journal of ophthalmology · 2023Article
- Alteration of perivascular reflectivity on optical coherence tomography of branched retinal vein obstruction.Scientific reports · 2023Article
- Choroideremia: The Endpoint Endgame.International journal of molecular sciences · 2023Review
- Clinical Applications of Optical Coherence Tomography Angiography in Inherited Retinal Diseases: An Up-to-Date Review of the Literature.Journal of clinical medicine · 2023Review
- Outer retinal and choriocapillaris modifications in choroideremia: three differentially impaired retinal regions and the potential diagnostic role of the external limiting membrane.Eye (London, England) · 2023Article
- Optical Coherence Tomography Angiography inJournal of clinical medicine · 2023Article
- Glial remodeling and choroidal vascular pathology in eyes from two donors with Choroideremia.Frontiers in ophthalmology · 2022Article
- Update on Gene Therapy Clinical Trials for Choroideremia and Potential Experimental Therapies.Medicina (Kaunas, Lithuania) · 2021Review
- Gene Therapy in Inherited Retinal Diseases: An Update on Current State of the Art.Frontiers in medicine · 2021Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundTo assess retinal layer thickness in choroideremia (CHM) and to reveal its correlation with optical coherence tomography (OCT) angiography (OCTA) findings.
methodsThe study was designed as an observational, cross-sectional clinical series of patients with CHM, which included 14 CHM eyes and 14 age-matched controls. Multimodal imaging included OCT and OCTA. The vessel density (VD) of superficial capillary (SCP), deep capillary (DCP) and choriocapillaris (CC) plexuses was analysed by OCTA. The apparently preserved retinal islet and atrophic regions were investigated separately. Main outcome measures were as follows: best-corrected visual acuity (BCVA), total retinal layers, ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), ellipsoid zone-retinal pigment epithelium (EZ-RPE) layer, choroidal thickness and VDs of SCP, DCP and of CC.
resultsMean BCVA was 0.0±0.0 LogMAR in both groups. GCL, ONL, EZ-RPE and choroid were significantly thinned in CHM, particularly in the atrophic region. OPL was unaffected in the apparently preserved islet, whereas INL and IPL were similarly thinned in the atrophic and apparently preserved retina. DCP appeared severely affected in both regions, while CC was only altered in the atrophic retina. Significant correlations were found between OCT and OCTA parameters.
conclusionsOur study showed severe alterations in both outer and inner retinal layers of patients with CHM. The extended retinal involvement might be the consequence of neuronal and vascular trophic factor reduction produced by the primarily altered RPE and/or secondary Müller glial cell reaction.
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Registered trials
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